Document Detail

Ventilatory drive during exercise in congestive heart failure.
MedLine Citation:
PMID:  9547439     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Continuous increases in the ventilatory equivalent for carbon dioxide (the ratio of minute ventilation to carbon dioxide production, an index of ventilatory drive) during exercise in patients with congestive heart failure would suggest that factors other than carbon dioxide excessively stimulate ventilation during exercise, and may be an important factor in exercise-related dyspnea and fatigue in these patients. METHODS AND RESULTS: Eighty-five patients with congestive heart failure and 17 normal control subjects underwent symptom-limited exercise testing with gas-exchange analysis. Patients were divided into four functional classes (A-D, Weber's classification) based on peak exercise oxygen consumption. In all heart failure patient groups and in control subjects the ventilatory equivalent for carbon dioxide decreased (P < .005, class D; P < .0001, all other groups) from rest to anaerobic threshold. Three isolated patients showed a continuous increase in ventilatory drive during exercise (mean peak oxygen consumption 13.7 mL/kg/min). In the lowest functional class (D) the ventilatory equivalent for carbon dioxide was greater than in all other groups at rest, at anaerobic threshold, and at peak exercise (P < .01). CONCLUSIONS: In all heart failure groups and in normal control subjects ventilatory drive, as determined by the ventilatory equivalent for carbon dioxide, decreases during exercise, Continuous increases in ventilatory drive during exercise are infrequently seen, suggesting that factors other than carbon dioxide production do not excessively stimulate ventilation in heart failure patients during exercise.
G A MacGowan; A Cecchetti; S Murali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  3     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-05-27     Completed Date:  1998-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM; S    
Division of Cardiology, University of Pittsburgh School of Medicine, Pennsylvania, USA.
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MeSH Terms
Anaerobic Threshold
Cardiac Output
Cardiomyopathy, Dilated / physiopathology
Exercise / physiology*
Heart Failure / physiopathology*
Middle Aged
Oxygen Consumption
Pulmonary Gas Exchange
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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