| Ventilatory control in parents of victims of sudden-infant-death syndrome. | |
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MedLine Citation:
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PMID: 7351974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since a defective ventilatory-control mechanism may have a role in the sudden-infant-death syndrome (SIDS), and hereditary factors influence the degree of ventilatory drive, we measured ventilatory responsiveness to carbon dioxide with and without increased airway resistance in 12 parents of SIDS victims and 12 control parents matched for age and size. Ventilatory response (delta VI/delta PCO2) and "respiratory drive" (delta P100/delta PCO2) were measured both with and without added resistance to inspiratory flow. SIDS parents had significantly lower ventilatory response with added resistance (P less than 0.05) and without it (P less than 0.01) and significantly lower respiratory drive with added resistance (P less than 0.001) and without it (P less than 0.05). Control parents had significantly increased respiratory drive when the resistance was added (P less than 0.005), whereas SIDS parents did not. The data suggest that a low ventilatory response to carbon dioxide and a diminished compensatory response to increased airway resistance may increase a potential parent's risk of having a child susceptible to SIDS. |
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Authors:
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P L Schiffman; R E Westlake; T V Santiago; N H Edelman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The New England journal of medicine Volume: 302 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1980 Feb |
Date Detail:
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Created Date: 1980-03-27 Completed Date: 1980-03-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 486-91 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Resistance Carbon Dioxide / diagnostic use Female Forced Expiratory Volume Humans Hypercapnia / physiopathology Male Parents Respiration* Sudden Infant Death / genetics, physiopathology* Vital Capacity |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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