Document Detail

Ventilatory control in normal man following five minutes' exposure to hypoxia.
MedLine Citation:
PMID:  4012094     Owner:  NLM     Status:  MEDLINE    
Ventilatory control was studied in normal subjects following brief (5 min) exposure to hypoxia (inhalation 7-8% O2). The ventilatory response to rebreathing CO2 (hyperoxic) was assessed 20 min before and after 5 min exposure to (a) 7-8% O2, (b) 7-8% O2 rebreathing CO2, (c) rebreathing CO2 during hyperoxia, and (d) 10% O2, normocapnic. The slope of the V-PCO2 response (S) was increased for up to 40 min following (a) and (b) by 25-34%, but was unchanged following (c) and (d). Resting ventilation was unchanged throughout. The ventilatory response to normocapnic progressive hypoxia was measured as the slope of the V-Hb% SaO2 relationship (H); this was increased by 26%. The mechanism underlying this change in ventilatory control in man is unknown; it may relate to the process of acclimatization to hypoxia whereby chronic hypoxia is a greater stimulus to ventilation than acute hypoxia.
A C Davidson; I R Cameron
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  60     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-08-16     Completed Date:  1985-08-16     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  227-36     Citation Subset:  IM    
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MeSH Terms
Anoxia / physiopathology*
Cardiovascular System / physiopathology
Hemoglobins / metabolism
Oxygen / blood
Time Factors
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

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