Document Detail

Ventilatory control during intermittent high-intensity exercise in humans.
MedLine Citation:
PMID:  18085272     Owner:  NLM     Status:  MEDLINE    
Intermittent supra-maximal cycling of varying work: recovery durations was used to explore the kinetics of respiratory compensation for the metabolic acidosis of high-intensity exercise (> lactate threshold, thetaL). For a 10:20s duty-cycle, blood [lactate] ([L-]) was not increased, and there was no evidence of respiratory compensation (RC); i.e, no increase in the ventilation (VE)-CO2 output (Vco2) slope, nor fall in end-tidal PCO2 (PETCO2). For longer duty-cycles, [L-] was elevated, stabilizing (30s:60 s exercise) or rising progressively (60s:120s, 90s: 180s exercise). In addition, Vco2 and VE now oscillated with WR, with evidence of delayed RC (progressive increase in VE - VCO2 slope; decrease in PETCO2) being more marked with longer duty-cycles. These results, which extend earlier findings with supra- thetaL step and ramp exercise, are not consistent with an appreciable contribution to RC from zero-order central command or peripheral neurogenesis. The reasons for the slow RC kinetics are unclear, but may reflect in part the H(+)-signal transduction properties of carotid chemoreceptors.
Andrew J Cathcart; Anthony P Turner; Christopher Butterworth; Matthew Parker; John Wilson; Susan A Ward
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  605     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-01-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  IM    
University of Glasgow, Institute of Biomedical & Life Sciences.
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MeSH Terms
Activity Cycles
Blood Gas Analysis
Carbon Dioxide / blood
Exercise / physiology*
Exercise Test
Oxygen / blood
Oxygen Consumption*
Respiratory Physiological Phenomena*
Tidal Volume
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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