| Ventilatory control during intermittent high-intensity exercise in humans. | |
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MedLine Citation:
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PMID: 18085272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intermittent supra-maximal cycling of varying work: recovery durations was used to explore the kinetics of respiratory compensation for the metabolic acidosis of high-intensity exercise (> lactate threshold, thetaL). For a 10:20s duty-cycle, blood [lactate] ([L-]) was not increased, and there was no evidence of respiratory compensation (RC); i.e, no increase in the ventilation (VE)-CO2 output (Vco2) slope, nor fall in end-tidal PCO2 (PETCO2). For longer duty-cycles, [L-] was elevated, stabilizing (30s:60 s exercise) or rising progressively (60s:120s, 90s: 180s exercise). In addition, Vco2 and VE now oscillated with WR, with evidence of delayed RC (progressive increase in VE - VCO2 slope; decrease in PETCO2) being more marked with longer duty-cycles. These results, which extend earlier findings with supra- thetaL step and ramp exercise, are not consistent with an appreciable contribution to RC from zero-order central command or peripheral neurogenesis. The reasons for the slow RC kinetics are unclear, but may reflect in part the H(+)-signal transduction properties of carotid chemoreceptors. |
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Authors:
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Andrew J Cathcart; Anthony P Turner; Christopher Butterworth; Matthew Parker; John Wilson; Susan A Ward |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 605 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2008 |
Date Detail:
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Created Date: 2007-12-18 Completed Date: 2008-01-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 203-8 Citation Subset: IM |
Affiliation:
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University of Glasgow, Institute of Biomedical & Life Sciences. A.Cathcart@bio.gla.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activity Cycles Blood Gas Analysis Carbon Dioxide / blood Exercise / physiology* Exercise Test Homeostasis Humans Male Oxygen / blood Oxygen Consumption* Respiratory Physiological Phenomena* Tidal Volume |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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