| Ventilatory compensation for lactacidosis in ponies: role of carotid chemoreceptors and lung afferents. | |
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MedLine Citation:
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PMID: 1909315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated changes in arterial PCO2 (PaCO2) and pulmonary ventilation (VE) in normal, carotid chemoreceptor-denervated, and hilar nerve-denervated ponies during intravenous lactic acid infusion at rest and treadmill exercise at 1.8 mph-5% grade (mild) and 1.8 mph-15% grade (moderate). Lactic acid, (0.5 M) infusion of 0.10, 0.13, and 0.20 ml.min-1.kg-1 at rest and mild and moderate exercise increased arterial [H+] linearly throughout the 10 min of acid infusion. At 10 min of infusion, arterial [H+] had increased approximately 20 nmol/l (0.2 pH units) for each condition and group. Under most conditions, the temporal pattern of PaCO2 during acid infusion was biphasic. At rest and during mild exercise in all groups, and in carotid chemoreceptor-denervated ponies during moderate exercise, PaCO2 increased approximately 2 Torr (P less than 0.05) during the first 2 min of acid infusion. However, in normal ponies during moderate exercise, PaCO2 was not changed from control in the first 2 min of infusion. Between 2 and 10 min of infusion at rest and mild and moderate exercise in all groups, there was a 5-Torr significant decrease in PaCO2, which did not differ (P greater than 0.10) between groups. VE increased between 15-30 s and 2 min of infusion, but VE changed minimally between 2 and 10 min of infusion at rest and exercise in all groups of ponies. We conclude that lactacidosis does increase VE at rest and submaximal exercise in the pony.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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B K Erickson; H V Forster; L G Pan; T F Lowry; D R Brown; M A Forster; A L Forster |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 70 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-10-08 Completed Date: 1991-10-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2619-26 Citation Subset: IM; S |
Affiliation:
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Department of Physiology, Medical College of Wisconsin, Milwaukee 53226. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Lactic
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complications,
physiopathology* Afferent Pathways / physiopathology Animals Carbon Dioxide / blood Carotid Body / physiopathology Chemoreceptor Cells / physiopathology Denervation Horses Hydrogen-Ion Concentration Hyperventilation / etiology, physiopathology Lung / innervation Physical Exertion / physiology Respiration / physiology* Respiratory Transport / physiology |
| Grant Support | |
ID/Acronym/Agency:
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5F32HL-07970-02/HL/NHLBI NIH HHS; HL-25739/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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