Document Detail

Ventilatory compensation for inspiratory resistive loads during anaesthesia with halothane or isoflurane.
MedLine Citation:
PMID:  10562777     Owner:  NLM     Status:  MEDLINE    
We have analysed the ventilatory response to sustained inspiratory resistive loads in 14 patients, while awake and during halothane (n = 7) or isoflurane (n = 7) anaesthesia. Patients breathed halothane or isoflurane in oxygen at 1.2 minimum alveolar concentration (MAC). Inspiratory resistances of 0, 12 and 37 cm H2O litre-1 s were applied. Tidal volume (VT) was maintained with the greater loads. At the greatest resistance, a significant reduction in minute ventilation occurred in both awake (-18.9%) and anaesthetized states, with both halothane (-10.4%) and isoflurane (-14.5%). Ventilatory frequency decreased significantly from mean 14.6 (SD 4.7) to 12.5 (4.3) bpm in the awake state and during anaesthesia, with increasing inspiratory resistance (29.5 (3.6) to 23.7 (7.2) bpm and 25.8 (3.3) to 23.4 (4.0) bpm, respectively, for halothane and isoflurane) because inspiratory time (TI) was significantly longer (P < 0.01). End-tidal PCO2 increased by 0.3 kPa, on average, from baseline to the highest level of resistance (P < 0.01). Inspiratory occlusion pressure at 100 ms increased significantly with increased loading in all situations (P < 0.001). We found a similar pattern of ventilatory adaptation to sustained inspiratory flow resistive loads both in awake and anaesthetized states. VT was maintained at increased loads because of an increase in inspiratory neuromuscular output and inspiratory duration.
J Canet; J Sanchis; P Vila; A Zegrí; C Llubià; F Vidal
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  82     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-11-16     Completed Date:  1999-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  847-51     Citation Subset:  IM    
Servei d'Anestesiologia i Reanimació, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.
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MeSH Terms
Airway Resistance / drug effects
Analysis of Variance
Anesthesia, Inhalation*
Anesthetics, Inhalation*
Lung / physiopathology*
Respiratory Mechanics / drug effects*
Tidal Volume / drug effects
Reg. No./Substance:
0/Anesthetics, Inhalation; 151-67-7/Halothane; 26675-46-7/Isoflurane

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