Document Detail

Ventilatory compensation for continuous inspiratory resistive and elastic loads during halothane anesthesia in humans.
MedLine Citation:
PMID:  2938523     Owner:  NLM     Status:  MEDLINE    
Inspiratory mechanical loads were applied to the airway continuously for 5 min in healthy young adult volunteers maintained in a near steady-state of halothane anesthesia 1.1 MAC. The loads, both flow resistive and elastic in nature, had been selected to reduce the first loaded tidal volume approximately 10, 30 or 50%--these being designated "small," "medium," and "large" loads, respectively. The actual magnitudes of resistive load were 8 +/- 1, 21 +/- 3, and 48 +/- 6 cmH2O X l-1 X s, and of elastic load 6 +/- 1, 18 +/- 1, and 41 +/- 5 cmH2O X l-1 (mean +/- SEM). All loads caused an immediate reduction of ventilation proportional to the size of the load. This was followed by a gradual recovery of ventilation toward control values over approximately 2 min and then nearly stable ventilation for the rest of the loading period. Respiratory frequency was unchanged throughout. At 5 min of loading, ventilation and PaCO2 had been nearly steady for 3 min and O2 uptake and CO2 output at the airway were unchanged from control, suggesting the establishment of a near steady respiratory state. With the small and medium loads of both types, ventilation and PaCO2 in this near steady-state were not detectably different from control. With the large loads, however, ventilation was significantly reduced and PaCO2 slightly increased. The end-expiratory position of the chest wall and the relative contributions of the rib cage and abdomen-diaphragm to ventilation, as estimated by anteroposterior chest wall magnetometers, were not consistently altered by any load.(ABSTRACT TRUNCATED AT 250 WORDS)
C A Moote; R L Knill; J Clement
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  64     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-05-22     Completed Date:  1986-05-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  582-9     Citation Subset:  AIM; IM; S    
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MeSH Terms
Abdominal Muscles / physiology
Anesthesia, Intratracheal*
Carbon Dioxide / analysis,  blood
Diaphragm / physiology
Functional Residual Capacity
Monitoring, Physiologic
Oxygen / blood
Pulmonary Gas Exchange
Pulmonary Ventilation
Respiration, Artificial*
Respiratory Dead Space
Thorax / physiology
Tidal Volume
Reg. No./Substance:
124-38-9/Carbon Dioxide; 151-67-7/Halothane; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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