| Ventilatory compensation for continuous inspiratory resistive and elastic loads during halothane anesthesia in humans. | |
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MedLine Citation:
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PMID: 2938523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inspiratory mechanical loads were applied to the airway continuously for 5 min in healthy young adult volunteers maintained in a near steady-state of halothane anesthesia 1.1 MAC. The loads, both flow resistive and elastic in nature, had been selected to reduce the first loaded tidal volume approximately 10, 30 or 50%--these being designated "small," "medium," and "large" loads, respectively. The actual magnitudes of resistive load were 8 +/- 1, 21 +/- 3, and 48 +/- 6 cmH2O X l-1 X s, and of elastic load 6 +/- 1, 18 +/- 1, and 41 +/- 5 cmH2O X l-1 (mean +/- SEM). All loads caused an immediate reduction of ventilation proportional to the size of the load. This was followed by a gradual recovery of ventilation toward control values over approximately 2 min and then nearly stable ventilation for the rest of the loading period. Respiratory frequency was unchanged throughout. At 5 min of loading, ventilation and PaCO2 had been nearly steady for 3 min and O2 uptake and CO2 output at the airway were unchanged from control, suggesting the establishment of a near steady respiratory state. With the small and medium loads of both types, ventilation and PaCO2 in this near steady-state were not detectably different from control. With the large loads, however, ventilation was significantly reduced and PaCO2 slightly increased. The end-expiratory position of the chest wall and the relative contributions of the rib cage and abdomen-diaphragm to ventilation, as estimated by anteroposterior chest wall magnetometers, were not consistently altered by any load.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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C A Moote; R L Knill; J Clement |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anesthesiology Volume: 64 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-05-22 Completed Date: 1986-05-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 582-9 Citation Subset: AIM; IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Muscles
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physiology Adult Anesthesia, Intratracheal* Carbon Dioxide / analysis, blood Diaphragm / physiology Female Functional Residual Capacity Halothane* Humans Male Monitoring, Physiologic Oximetry Oxygen / blood Pulmonary Gas Exchange Pulmonary Ventilation Respiration* Respiration, Artificial* Respiratory Dead Space Thorax / physiology Tidal Volume |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 151-67-7/Halothane; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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