Document Detail

Ventilatory compensation for changes in posture after human heart-lung transplantation.
MedLine Citation:
PMID:  2799111     Owner:  NLM     Status:  MEDLINE    
We have studied the contribution of vagal pulmonary receptors to the stability of breathing during postural changes in humans. Quiet breathing was quantified in the seated and the supine postures in 10 patients with chronic pulmonary denervation due to heart-lung transplantation and 10 age and sex matched normal controls. In the vast majority of patients and normal subjects frequency histograms for tidal volume and mean inspiratory flow rate were virtually superimposed seated and supine. There were no significant differences in the mean levels of respiratory variables between postures in either group (except for mean inspiratory flow rate in the patients which was slightly greater seated than supine). Experiments performed on a tilt table in two additional patients showed that the ventilatory response to postural changes was immediate. In addition, the response was maintained after blockade of intact tracheal stretch receptors with aerosolized lidocaine. These results indicate that adequate ventilatory compensation during postural changes does not depend on vagal afferent information arising in intrapulmonary or tracheal airway stretch receptors. The appropriate receptors may be diaphragmatic Golgi tendon organs.
W Kinnear; T Higenbottam; D Shaw; J Wallwork; M Estenne
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  77     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-30     Completed Date:  1989-10-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  75-88     Citation Subset:  IM    
Department of Respiratory Physiology, Papworth Hospital, Huntingdon, U.K.
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MeSH Terms
Afferent Pathways
Forced Expiratory Volume
Heart Transplantation*
Inspiratory Capacity
Lung Transplantation*
Lung Volume Measurements
Middle Aged
Respiratory Muscles / innervation
Respiratory Physiological Phenomena*
Tidal Volume
Vagus Nerve

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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