Document Detail

Ventilatory and cardiac responses to pulmonary embolism: consequences for gas exchange and blood pressure.
MedLine Citation:
PMID:  23367456     Owner:  NLM     Status:  MEDLINE    
Acute thromboembolic pulmonary embolism (PE) is a life threatening condition that can lead to pulmonary hypertension and right ventricular dysfunction or failure. There is typically an increase in ventilation rate and cardiac output as a response to PE prior to cardiac failure, which is at least in part due to systemic hypoxemia. Here we assess the response of the lungs to changes in these parameters using anatomically-based computational models of pulmonary perfusion, ventilation and gas exchange. We show that increases in ventilation and cardiac output improve overall gas exchange in PE. However, this comes at the cost of an increased pulmonary blood pressure, which may contribute to pulmonary hypertension as a result of PE.
Alys R Clark; Mohit Bajaj; Margaret L Wilsher; David G Milne; Merryn H Tawhai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2012     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-09-17     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6657-60     Citation Subset:  IM    
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MeSH Terms
Anoxia / pathology
Blood Pressure
Carbon Dioxide / metabolism
Cardiac Output
Computer Simulation
Hypertension / pathology
Lung / pathology
Models, Anatomic
Pulmonary Embolism / physiopathology*
Pulmonary Gas Exchange*
Tachycardia / pathology
Tomography, X-Ray Computed
Ventricular Dysfunction, Right / pathology
Reg. No./Substance:
142M471B3J/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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