Document Detail

Ventilatory behavior after hypoxia in C57BL/6J and A/J mice.
MedLine Citation:
PMID:  11641331     Owner:  NLM     Status:  MEDLINE    
Given the environmental forcing by extremes in hypoxia-reoxygenation, there might be no genetic effect on posthypoxic short-term potentiation of ventilation. Minute ventilation (VE), respiratory frequency (f), tidal volume (VT), and the airway resistance during chemical loading were assessed in unanesthetized unrestrained C57BL/6J (B6) and A/J mice using whole body plethysmography. Static pressure-volume curves were also performed. In 12 males for each strain, after 5 min of 8% O2 exposure, B6 mice had a prominent decrease in VE on reoxygenation with either air (-11%) or 100% O2 (-20%), due to the decline of f. In contrast, A/J animals had no ventilatory undershoot or f decline. After 5 min of 3% CO2-10% O2 exposure, B6 exhibited significant decrease in VE (-28.4 vs. -38.7%, air vs. 100% O2) and f (-13.8 vs. -22.3%, air vs. 100% O2) during reoxygenation with both air and 100% O2; however, A/J mice showed significant increase in VE (+116%) and f (+62.2%) during air reoxygenation and significant increase in VE (+68.2%) during 100% O2 reoxygenation. There were no strain differences in dynamic airway resistance during gas challenges or in steady-state total respiratory compliance measured postmortem. Strain differences in ventilatory responses to reoxygenation indicate that genetic mechanisms strongly influence posthypoxic ventilatory behavior.
F Han; S Subramanian; T E Dick; I A Dreshaj; K P Strohl
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  91     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-19     Completed Date:  2002-01-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1962-70     Citation Subset:  IM    
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.
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MeSH Terms
Airway Resistance / physiology
Anoxia / physiopathology*
Behavior, Animal / physiology*
Carbon Dioxide / metabolism
Chemoreceptor Cells / physiology
Mice, Inbred A
Mice, Inbred C57BL
Oxygen Consumption / physiology
Respiratory Function Tests
Respiratory Mechanics / physiology*
Species Specificity
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide

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