| Ventilatory behavior after hypoxia in C57BL/6J and A/J mice. | |
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MedLine Citation:
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PMID: 11641331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Given the environmental forcing by extremes in hypoxia-reoxygenation, there might be no genetic effect on posthypoxic short-term potentiation of ventilation. Minute ventilation (VE), respiratory frequency (f), tidal volume (VT), and the airway resistance during chemical loading were assessed in unanesthetized unrestrained C57BL/6J (B6) and A/J mice using whole body plethysmography. Static pressure-volume curves were also performed. In 12 males for each strain, after 5 min of 8% O2 exposure, B6 mice had a prominent decrease in VE on reoxygenation with either air (-11%) or 100% O2 (-20%), due to the decline of f. In contrast, A/J animals had no ventilatory undershoot or f decline. After 5 min of 3% CO2-10% O2 exposure, B6 exhibited significant decrease in VE (-28.4 vs. -38.7%, air vs. 100% O2) and f (-13.8 vs. -22.3%, air vs. 100% O2) during reoxygenation with both air and 100% O2; however, A/J mice showed significant increase in VE (+116%) and f (+62.2%) during air reoxygenation and significant increase in VE (+68.2%) during 100% O2 reoxygenation. There were no strain differences in dynamic airway resistance during gas challenges or in steady-state total respiratory compliance measured postmortem. Strain differences in ventilatory responses to reoxygenation indicate that genetic mechanisms strongly influence posthypoxic ventilatory behavior. |
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Authors:
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F Han; S Subramanian; T E Dick; I A Dreshaj; K P Strohl |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 91 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-19 Completed Date: 2002-01-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1962-70 Citation Subset: IM |
Affiliation:
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Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance
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physiology Animals Anoxia / physiopathology* Behavior, Animal / physiology* Carbon Dioxide / metabolism Chemoreceptor Cells / physiology Environment Male Mice Mice, Inbred A Mice, Inbred C57BL Oxygen Consumption / physiology Respiratory Function Tests Respiratory Mechanics / physiology* Species Specificity |
| Grant Support | |
ID/Acronym/Agency:
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HL-07193/HL/NHLBI NIH HHS; HL-58380/HL/NHLBI NIH HHS; HL-97015/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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