Document Detail

Ventilatory adjustments during sustained mechanical loading in conscious humans.
MedLine Citation:
PMID:  6629954     Owner:  NLM     Status:  MEDLINE    
Ventilatory responses to inspiratory elastic and resistive loads of 67 men were analyzed. During the 1st, 5th, and 10th consecutively loaded breaths 1) individual responses ranged from a rapid-shallow to a slow-deep breathing pattern; 2) strong tidal volume (VT) defenders employed longer inspirations than did weak VT defenders; and 3) individual frequency responses were mediated by changes in inspiratory and/or expiratory timing. Thus the group response was qualitatively similar on the 1st, 5th, and 10th loaded breaths. Quantitatively, however, the group's mean minute ventilation increased throughout each episode owing to progressively larger tidal volumes coupled with equal breathing frequencies. During elastic loading this amplified VT defense was achieved by stronger inspirations with no systematic changes in timing, whereas during resistive loading it was achieved both by stronger and longer inspirations. Inspiring 5% CO2 induced a degree of hypercapnia exceeding that accompanying mechanical loading and yet elicited a comparatively modest enhancement of respiratory output. These findings suggest that in conscious humans 1) repeated mechanical loading activates neural load-compensating mechanisms; 2) the range of these neural adjustments varies with both load size and type; and 3) the stimulus to initiate this behavior is largely nonchemical.
K Axen; S S Haas; F Haas; D Gaudino; A Haas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  55     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1211-8     Citation Subset:  IM    
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MeSH Terms
Pulmonary Ventilation
Tidal Volume
Time Factors
Work of Breathing*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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