Document Detail

Ventilatory Response to Hypercarbia in Newborns of Smoking and Substance Misusing Mothers.
MedLine Citation:
PMID:  24983462     Owner:  NLM     Status:  Publisher    
Rationale: Infants of mothers who smoked (S) or substance misused (SM) during pregnancy have an increased risk of sudden infant death syndrome (SIDS). Objectives: To test the hypothesis that infants of S and SM mothers compared to infants of non substance misusing, non-smoking mothers (controls) would have a reduced ventilatory response to hypercarbia and that any reduction would be greater in the SM infants. Methods: Infants were assessed before maternity/neonatal unit discharge. Maternal and infant urine samples were obtained and tested for cotinine, cannabinoids, opiates, amphetamines, methadone, cocaine and benzodiazepines. Measurements and main results: Respiratory flow and tidal volume were measured using a pneumotachograph inserted into a face mask placed over the infant's mouth and nose. The ventilatory responses to three levels of inspired carbon dioxide (0% (baseline), 2% and 4% CO2) were assessed. Twenty-three SM, 34 S and 22 control infants were assessed. The birth weight of the controls was higher than the SM and S infants (p=0.017). At baseline, SM infants had a higher respiratory rate (p=0.003) and minute volume (p=0.007) compared to controls and S infants. Both the SM and S infants had a lower ventilatory response to 2% (p<0.001) and 4% (p<0.001) CO2 than the controls. The ventilatory response to CO2 was lower in the SM infants compared to the S infants (p=0.009). Conclusions: These results are consistent with infants of smoking mothers and substance misuse/smoking mothers having a dampened ventilatory response to hypercarbia, which is particularly marked in the latter group.
Kamal Ali; Kim Wolff; Janet L Peacock; Simon Hannam; Gerrard F Rafferty; Ravindra Bhat; Anne Greenough
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-1
Journal Detail:
Title:  Annals of the American Thoracic Society     Volume:  -     ISSN:  2325-6621     ISO Abbreviation:  Ann Am Thorac Soc     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101600811     Medline TA:  Ann Am Thorac Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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