| Ventilatory and PaCO2 responses to voluntary and electrically induced leg exercise. | |
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MedLine Citation:
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PMID: 3128524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the role of central command mediation of exercise hyperpnea by comparing the ventilatory and arterial CO2 partial pressure (PaCO2) responses to voluntary (ExV) and electrically induced (ExE) muscle contractions in normal, awake human subjects. We hypothesized that if central command signals are critical to a normal ventilatory response, then ExE should cause a slower ventilatory response resulting in hypercapnia at the onset of exercise. ExE was induced through surface electrodes placed over the quadriceps and hamstring muscles. ExE and ExV produced leg extension (40/min) against a spring load that increased CO2 production (VCO2) 100-1,000 ml/min above resting level. PaCO2 and arterial pH during work transitions and in the steady state did not differ significantly from rest (P greater than 0.05) or between ExE and ExV. The temporal pattern of ventilation, tidal volume, breathing frequency, and inspired and expired times, and the ventilation-VCO2 relationship were similar between ExE and ExV. We conclude that since central command was reduced and/or eliminated by ExE, central command is not requisite for the precise matching of alveolar ventilation to increases in VCO2 during low-intensity muscle contractions. |
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Authors:
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A G Brice; H V Forster; L G Pan; A Funahashi; T F Lowry; C L Murphy; M D Hoffman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 64 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-05-13 Completed Date: 1988-05-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 218-25 Citation Subset: IM; S |
Affiliation:
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Department of Physiology, Medical College of Wisconsin, Milwaukee 53226. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Dioxide / blood* Electric Stimulation Female Humans Leg / physiology* Male Muscle Contraction Muscles / physiology* Partial Pressure Physical Exertion* Respiration* |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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