| Ventilatory Inefficiency as a Limiting Factor for Exercise in Patients With COPD. | |
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MedLine Citation:
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PMID: 22005099 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Evaluate the influence of ventilatory inefficiency over exercise capacity in COPD patients. Rationale: Ventilatory inefficiency increase ventilatory demand. Corresponds to an abnormal increased in VE/VCO₂ and represents increased dead space, deregulation of respiratory control and early lactic threshold. Associated with expiratory flow limitation enhance DH and may limitate exercise capacity Method: Prospective study of 35 COPD patients with different levels of severity to whom cardiopulmonary stress test (CPET) was performed. Ventilatory inefficiency was represented by VE/VCO₂ relation. Its influence over maximal oxygen consumption (VO₂max), power (W), and ventilatory threshold (AT) were evaluated. Surrogate parameters of cardiac function, like oxygen pulse (VO₂/HR) and circulatory power (CP) = %VO₂max x peak systolic pressure, were also evaluated. RESULTS: CPET was stopped due to dyspnea with elevated minute ventilation (VE) and marked reduction of breathing reserve (BR). A severe increase in VE/VCO₂ (mean: 35.9, SD 5.6), a decrease of VO₂max (mean 75.2%, SD 20) and a decrease of W (mean 68.6%, SD 23.3) were demonstrated. 28 patients presented dynamic hyperinflation (DH). Lineal regression showed a reduction of 2.04% on VO₂max (p<0,001), 2.6% on W (p<0,001), 1% of VO₂/HR (p <0,05), and 322,7 units of CP (p=0,02), per each unit of increment in VE/VCO₂ respectively. CONCLUSION: Ventilatory inefficiency correlates with a reduction in exercise capacity in COPD patients. Including this parameter in the evaluation of exercise limitation in this patient population, may mean a contribution towards the understanding of its physiopathology. |
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Authors:
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Iván R Caviedes; Iris Delgado; Rodrigo Soto |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-13 |
Journal Detail:
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Title: Respiratory care Volume: - ISSN: 0020-1324 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7510357 Medline TA: Respir Care Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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