Document Detail

Ventilator or physician-induced lung injury?
MedLine Citation:
PMID:  15886585     Owner:  NLM     Status:  MEDLINE    
One of the most challenging problems in critical care medicine is the acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI). Evidence from experimental studies suggests that mechanical ventilation can cause or aggravate lung injury. Referred to as ventilator-induced lung injury (VILI), this condition resembles ALI and ARDS, and is difficult to identify in humans because its appearance overlaps the underlying disease, supporting the assumption that mechanical ventilation can extend the severity of pre-existent lung injury. There is increasing laboratory evidence that ventilating ARDS models with relatively low tidal volumes and high levels of positive end-expiratory pressure (PEEP) is clinically beneficial. In 2000, the ARDS Network published reported a reduced mortality (from 40% to 31%) in a mixed population of patients with ALI and ARDS ventilated with half the tidal volume of the control group. However, almost forty years after the first description of ARDS, many investigators and experts in the field still apply essentially the same ventilatory strategy (tidal volume greater than 10 mL/kg body weight and PEEP levels less than 10 cmH2O) as in the original description of ARDS.
J Villar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Minerva anestesiologica     Volume:  71     ISSN:  0375-9393     ISO Abbreviation:  Minerva Anestesiol     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-11     Completed Date:  2005-08-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375272     Medline TA:  Minerva Anestesiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  255-8     Citation Subset:  IM    
Research Institute, Hospital Universitario N.S. of Candelaria, Tenerife, Canary Islands, Spain.
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MeSH Terms
Iatrogenic Disease
Lung Diseases / epidemiology,  etiology*
Lung Injury*
Respiration, Artificial / adverse effects*
Respiratory Distress Syndrome, Adult / complications,  physiopathology,  therapy
Tidal Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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