| Ventilator-associated sinusitis in adults: Systematic review and meta-analysis. | |
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MedLine Citation:
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PMID: 22521223 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To review the epidemiology, risk factors for, treatment and outcome of ventilator-associated sinusitis (VAS). METHODS: We performed a systematic review and meta-analysis of available data without time restrictions. A conservative random effects model was employed to calculate pooled odds ratios (OR) and 95% confidence intervals (CIs). RESULTS: Out of 620 retrieved reports, 31 papers fulfilled our inclusion criteria. Infectious sinusitis affects 27% of mechanically ventilated patients and was found to be the cause of undetermined fever in 25% of the cases. Although radiographic VAS was higher in nasotracheally compared to orotracheally intubated patients (OR 4.66, 95% CI 1.35-16.13), clinical VAS was not (3.67, 0.80-6.81). The presence of VAS has been associated with the presence of VAP (3.66, 1.81-7.37) or bacteremia (6.85, 2.14, 21.92); however, it is unknown whether an etiologic relationship between them exists. In patients with concomitant VAS and VAP or bloodstream infections identical pathogens are isolated in 59% and 20% of the cases, respectively. The presence as opposed to absence of VAS was not associated with excess mortality (1.02, 0.35-3.01). CONCLUSION: VAS is a common infection in critically ill adults and correlates with other important infectious complications. |
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Authors:
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Michalis Agrafiotis; Konstantinos Z Vardakas; Ioannis D Gkegkes; Anastasios Kapaskelis; Matthew E Falagas |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-19 |
Journal Detail:
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Title: Respiratory medicine Volume: - ISSN: 1532-3064 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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