Document Detail

Ventilator-associated pneumonia and its prevention.
MedLine Citation:
PMID:  22744316     Owner:  NLM     Status:  Publisher    
PURPOSE OF REVIEW: Given that ventilator-associated pneumonia (VAP) causes substantial morbidity, mortality and costs, prevention of this infectious process is a major challenge. RECENT FINDINGS: This study provides an update on the prevention of VAP, focusing on the ability of preventive measures to improve patient outcomes and concentrating wherever possible on the data published within the past 5 years. Particular attention is be paid to the latest approach to facilitate the implementation of those prevention measures known as 'care bundles'. SUMMARY: Several preventive measures have been shown to reduce the rate of VAP but many less have demonstrated an impact on patient outcomes (noninvasive positive pressure ventilation, sedation and weaning protocols, selective digestive and oral decontamination and endotracheal tube with drainage of subglottic secretions). Patients at risk must be approached with a bundle of preventive measures. Beyond the theoretical frame, a great deal of attention must be given to the factors that might improve adherence to those preventive measures. Future clinical trials testing new strategies in preventing VAP should have patient outcomes (i.e. a reduction in the length under mechanical ventilation, in the duration of stay in healthcare settings or in antibiotic consumption) as primary end-points rather than VAP rates.
Lila Bouadma; Michel Wolff; Jean-Christophe Lucet
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  -     ISSN:  1473-6527     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aService de Réanimation Médicale et des Maladies Infectieuses bUnité d'Hygiène et de Lutte contre l'Infection Nosocomiale, Hôpital Bichat-Claude-Bernard, Assistance Publique - Hôpitaux de Paris cUniversité Paris Diderot, Sorbonne Paris Cité, Paris, France.
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