Document Detail


Ventilation-perfusion distributions and gas exchange during carbon dioxide-pneumoperitoneum in a porcine model.
MedLine Citation:
PMID:  20693177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Carbon dioxide (CO₂)-pneumoperitoneum (PP) of 12 mm Hg increases arterial oxygenation, but it also promotes collapse of dependent lung regions. This seeming paradox prompted the present animal study on the effects of PP on ventilation-perfusion distribution (V/Q) and gas exchange. METHODS: Fourteen anaesthetized pigs were studied. In seven pigs, single photon emission computed tomography (SPECT) was used for spatial analysis of ventilation and perfusion distributions, and in another seven pigs, multiple inert gas elimination technique (MIGET) was used for detailed analysis of V/Q matching. SPECT/MIGET and central haemodynamics and pulmonary gas exchange were recorded during anaesthesia before and 60 min after induction of PP. RESULTS: SPECT during PP showed no or only poorly ventilated regions in the dependent lung compared with the ventilation distribution during anaesthesia before PP. PP was accompanied by redistribution of blood flow away from the non- or poorly ventilated regions. V/Q analysis by MIGET showed decreased shunt from 9 (sd 2) to 7 (2)% after induction of PP (P<0.05). No regions of low V/Q were seen either before or during PP. Almost no regions of high V/Q developed during PP (1% of total ventilation). Pa(o₂) increased from 33 (1.2) to 35.7 (3.2) kPa (P<0.01) and arterial to end-tidal Pco₂ gradient (Pae'(co₂) increased from 0.3 (0.1) to 0.6 (0.2) kPa (P<0.05). CONCLUSIONS: Perfusion was redistributed away from dorsal, collapsed lung regions when PP was established. This resulted in a better V/Q match. A possible mechanism is enhanced hypoxic pulmonary vasoconstriction.
Authors:
C M Strang; F Fredén; E Maripuu; T Hachenberg; G Hedenstierna
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Publication Detail:
Type:  Journal Article     Date:  2010-08-06
Journal Detail:
Title:  British journal of anaesthesia     Volume:  105     ISSN:  1471-6771     ISO Abbreviation:  Br J Anaesth     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2010-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  691-7     Citation Subset:  IM    
Affiliation:
Department of Medical Sciences and Clinical Physiology, Uppsala University, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General
Animals
Carbon Dioxide / blood
Hemodynamics / physiology
Laparoscopy
Models, Animal
Monitoring, Physiologic / methods
Oxygen / blood
Partial Pressure
Pneumoperitoneum, Artificial / methods*
Pulmonary Gas Exchange / physiology*
Respiration, Artificial / methods
Sus scrofa
Tomography, Emission-Computed, Single-Photon
Ventilation-Perfusion Ratio / physiology*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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