| Ventilation and oxygen: dose-related effects of oxygen on ventilation-induced lung injury. | |
| | |
MedLine Citation:
|
PMID: 20010313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Preterm infants are at high risk of developing ventilator-induced lung injury. We have used an animal model of in utero ventilation (IUV) to investigate the separate effects of ventilation and acute oxygen exposure on the very immature lung. Fetal sheep were ventilated in utero at 110 d gestation for 6 h with 100, 21, or 0% (100% nitrogen) oxygen (n = 5 each) and survived in utero, without further ventilation, until tissue collection at 118 d. Nonventilated 110 d and 118 d fetuses were used as controls. All IUV exposed fetuses had reduced secondary septal crest densities and increased elastin staining irrespective of the inspired oxygen concentration. IUV with 100% and 21% oxygen, but not 100% nitrogen, increased lung tissue volumes and myofibroblast differentiation and apoptosis within the distal lung parenchyma in a dose-dependent manner. This study shows that IUV without oxygen can reduce alveolarization, whereas ventilation with oxygen (6 h), even at levels found in air (21%), increases distal lung tissue volumes, elastin deposition, myofibroblast differentiation, and apoptosis. |
| | |
Authors:
|
Beth J Allison; Kelly J Crossley; Sharon J Flecknoe; Peter G Davis; Colin J Morley; Stuart B Hooper |
Related Documents
:
|
2248693 - Unusual observations on hypermagnesemic levels and cardiorespiratory effects in neonata... 367233 - Topographical ventilation and perfusion distribution during ippb in the lateral posture. 8857483 - Estimation of pulmonary artery pressure by spectral analysis of the second heart sound. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pediatric research Volume: 67 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-15 Completed Date: 2010-04-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
|
Languages: eng Pagination: 238-43 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Monash University, Victoria, Australia. beth.allison@med.monash.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apoptosis / drug effects Carbon Dioxide / blood Caspase 3 / metabolism Cell Differentiation / drug effects Collagen / metabolism Disease Models, Animal Dose-Response Relationship, Drug Elastin / metabolism Female Fetal Blood / metabolism Fibroblasts / drug effects, pathology Gestational Age Lung / drug effects*, embryology, metabolism Oxygen / blood Oxygen Inhalation Therapy / adverse effects* Positive-Pressure Respiration / adverse effects* Pregnancy Sheep Time Factors Ventilator-Induced Lung Injury / blood, embryology, therapy* |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 9007-34-5/Collagen; 9007-58-3/Elastin; EC 3.4.22.-/Caspase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunogenicity of a Reduced Schedule of Pneumococcal Conjugate Vaccine in Healthy Infants and Correl...
Next Document: Resuscitation of Hypoxic Newborn Piglets with Supplementary Oxygen induces Dose-dependent Increase i...