Document Detail

Ventilation and oxygen: dose-related effects of oxygen on ventilation-induced lung injury.
MedLine Citation:
PMID:  20010313     Owner:  NLM     Status:  MEDLINE    
Preterm infants are at high risk of developing ventilator-induced lung injury. We have used an animal model of in utero ventilation (IUV) to investigate the separate effects of ventilation and acute oxygen exposure on the very immature lung. Fetal sheep were ventilated in utero at 110 d gestation for 6 h with 100, 21, or 0% (100% nitrogen) oxygen (n = 5 each) and survived in utero, without further ventilation, until tissue collection at 118 d. Nonventilated 110 d and 118 d fetuses were used as controls. All IUV exposed fetuses had reduced secondary septal crest densities and increased elastin staining irrespective of the inspired oxygen concentration. IUV with 100% and 21% oxygen, but not 100% nitrogen, increased lung tissue volumes and myofibroblast differentiation and apoptosis within the distal lung parenchyma in a dose-dependent manner. This study shows that IUV without oxygen can reduce alveolarization, whereas ventilation with oxygen (6 h), even at levels found in air (21%), increases distal lung tissue volumes, elastin deposition, myofibroblast differentiation, and apoptosis.
Beth J Allison; Kelly J Crossley; Sharon J Flecknoe; Peter G Davis; Colin J Morley; Stuart B Hooper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  67     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-43     Citation Subset:  IM    
Department of Physiology, Monash University, Victoria, Australia.
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MeSH Terms
Apoptosis / drug effects
Carbon Dioxide / blood
Caspase 3 / metabolism
Cell Differentiation / drug effects
Collagen / metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Elastin / metabolism
Fetal Blood / metabolism
Fibroblasts / drug effects,  pathology
Gestational Age
Lung / drug effects*,  embryology,  metabolism
Oxygen / blood
Oxygen Inhalation Therapy / adverse effects*
Positive-Pressure Respiration / adverse effects*
Time Factors
Ventilator-Induced Lung Injury / blood,  embryology,  therapy*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 9007-34-5/Collagen; 9007-58-3/Elastin; EC 3.4.22.-/Caspase 3

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