Document Detail

Ventilation-mediated injury after preterm delivery of Ureaplasma parvum colonized fetal lambs.
MedLine Citation:
PMID:  20220549     Owner:  NLM     Status:  MEDLINE    
Ureaplasma species are the microorganisms most frequently isolated from women with preterm birth and are associated with an increased risk of bronchopulmonary dysplasia. Initiation of ventilation with high tidal volumes (VT) causes lung injury and inflammation. We investigated whether antenatal colonization with Ureaplasma parvum serovar 3 (UP) would alter the inflammatory response to mechanical ventilation of preterm lambs. Merino ewes were given intraamniotic injections of UP at 55-d gestation, and the lambs were surgically delivered at 128+/-1 d gestation and assigned to three groups: 1) gentle ventilation (GV), 2) high VT ventilation, or 3) unventilated control. Lambs delivered from noncolonized ewes were assigned to parallel groups. GV lambs received surfactant before ventilation with a VT of 7 mL/kg, positive end expiratory pressure (PEEP) 5 cm H2O. High VT lambs received no PEEP and escalating VT to 15 mL/kg by 15 min. At 15 min, surfactant was given, VT was reduced to 7 mL/kg, and PEEP was increased to 5 cm H2O. Monocytes in bronchoalveolar lavage were increased by UP, but colonization did not affect lung function. High VT ventilation increased Egr-1 signaling, proinflammatory cytokine expression, and injury scores compared with GV. Antenatal colonization with UP did not change lung function or modulate the lung injury and inflammation caused by high VT ventilation.
Graeme R Polglase; Noah H Hillman; J Jane Pillow; Ilias Nitsos; John P Newnham; Christine L Knox; Suhas G Kallapur; Alan H Jobe
Related Documents :
9504789 - Cardiopulmonary interaction during partial liquid ventilation in surfactant-treated pre...
12357049 - Albumin mixed with meconium attenuates pulmonary dysfunction in a newborn piglet model ...
24084759 - Direct measurement of osmotic pressure via adaptive confinement of quasi hard disc coll...
15876559 - Effect of surfactant deficiency and surfactant replacement on airway patency in the pig...
12153979 - Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury.
2453499 - Effect of increased surface tension and assisted ventilation on 99mtc-dtpa clearance.
11445709 - Induced abdominal compartment syndrome increases intracranial pressure in neurotrauma p...
16325189 - Linear voltage profiles and flow homogeneity in pressurized planar electrochromatography.
21410199 - Co1-xmgxmoo4 compounds for pressure indicators.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  67     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  630-5     Citation Subset:  IM    
School of Women's and Infants' Health, The University of Western Australia, Subiaco, Western Australia 6009, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bronchoalveolar Lavage Fluid / immunology,  microbiology
Disease Models, Animal
Gestational Age
Inflammation Mediators / metabolism
Lung / immunology,  microbiology*,  pathology,  physiopathology
Monocytes / immunology,  microbiology
Positive-Pressure Respiration / adverse effects*
Pregnancy Complications, Infectious / immunology,  microbiology*
Premature Birth / immunology,  microbiology*,  physiopathology,  therapy*
Pulmonary Surfactants / pharmacology
Tidal Volume
Time Factors
Ureaplasma / pathogenicity*
Ureaplasma Infections / complications,  immunology,  microbiology*
Ventilator-Induced Lung Injury / etiology*,  immunology,  physiopathology,  prevention & control
Grant Support
12714//PHS HHS; K08HL097085/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Inflammation Mediators; 0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Placental restriction increases adipose leptin gene expression and plasma leptin and alters their re...
Next Document:  Vitamin A and retinoic acid act synergistically to increase lung retinyl esters during normoxia and ...