Document Detail


Ventilation-mediated injury after preterm delivery of Ureaplasma parvum colonized fetal lambs.
MedLine Citation:
PMID:  20220549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ureaplasma species are the microorganisms most frequently isolated from women with preterm birth and are associated with an increased risk of bronchopulmonary dysplasia. Initiation of ventilation with high tidal volumes (VT) causes lung injury and inflammation. We investigated whether antenatal colonization with Ureaplasma parvum serovar 3 (UP) would alter the inflammatory response to mechanical ventilation of preterm lambs. Merino ewes were given intraamniotic injections of UP at 55-d gestation, and the lambs were surgically delivered at 128+/-1 d gestation and assigned to three groups: 1) gentle ventilation (GV), 2) high VT ventilation, or 3) unventilated control. Lambs delivered from noncolonized ewes were assigned to parallel groups. GV lambs received surfactant before ventilation with a VT of 7 mL/kg, positive end expiratory pressure (PEEP) 5 cm H2O. High VT lambs received no PEEP and escalating VT to 15 mL/kg by 15 min. At 15 min, surfactant was given, VT was reduced to 7 mL/kg, and PEEP was increased to 5 cm H2O. Monocytes in bronchoalveolar lavage were increased by UP, but colonization did not affect lung function. High VT ventilation increased Egr-1 signaling, proinflammatory cytokine expression, and injury scores compared with GV. Antenatal colonization with UP did not change lung function or modulate the lung injury and inflammation caused by high VT ventilation.
Authors:
Graeme R Polglase; Noah H Hillman; J Jane Pillow; Ilias Nitsos; John P Newnham; Christine L Knox; Suhas G Kallapur; Alan H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  67     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  630-5     Citation Subset:  IM    
Affiliation:
School of Women's and Infants' Health, The University of Western Australia, Subiaco, Western Australia 6009, Australia. graeme.polglase@uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Bronchoalveolar Lavage Fluid / immunology,  microbiology
Disease Models, Animal
Female
Gestational Age
Inflammation Mediators / metabolism
Lung / immunology,  microbiology*,  pathology,  physiopathology
Monocytes / immunology,  microbiology
Positive-Pressure Respiration / adverse effects*
Pregnancy
Pregnancy Complications, Infectious / immunology,  microbiology*
Premature Birth / immunology,  microbiology*,  physiopathology,  therapy*
Pulmonary Surfactants / pharmacology
Sheep
Tidal Volume
Time Factors
Ureaplasma / pathogenicity*
Ureaplasma Infections / complications,  immunology,  microbiology*
Ventilator-Induced Lung Injury / etiology*,  immunology,  physiopathology,  prevention & control
Grant Support
ID/Acronym/Agency:
12714//PHS HHS; K08HL097085/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Inflammation Mediators; 0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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