| Ventilation-mediated injury after preterm delivery of Ureaplasma parvum colonized fetal lambs. | |
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MedLine Citation:
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PMID: 20220549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ureaplasma species are the microorganisms most frequently isolated from women with preterm birth and are associated with an increased risk of bronchopulmonary dysplasia. Initiation of ventilation with high tidal volumes (VT) causes lung injury and inflammation. We investigated whether antenatal colonization with Ureaplasma parvum serovar 3 (UP) would alter the inflammatory response to mechanical ventilation of preterm lambs. Merino ewes were given intraamniotic injections of UP at 55-d gestation, and the lambs were surgically delivered at 128+/-1 d gestation and assigned to three groups: 1) gentle ventilation (GV), 2) high VT ventilation, or 3) unventilated control. Lambs delivered from noncolonized ewes were assigned to parallel groups. GV lambs received surfactant before ventilation with a VT of 7 mL/kg, positive end expiratory pressure (PEEP) 5 cm H2O. High VT lambs received no PEEP and escalating VT to 15 mL/kg by 15 min. At 15 min, surfactant was given, VT was reduced to 7 mL/kg, and PEEP was increased to 5 cm H2O. Monocytes in bronchoalveolar lavage were increased by UP, but colonization did not affect lung function. High VT ventilation increased Egr-1 signaling, proinflammatory cytokine expression, and injury scores compared with GV. Antenatal colonization with UP did not change lung function or modulate the lung injury and inflammation caused by high VT ventilation. |
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Authors:
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Graeme R Polglase; Noah H Hillman; J Jane Pillow; Ilias Nitsos; John P Newnham; Christine L Knox; Suhas G Kallapur; Alan H Jobe |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 67 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 630-5 Citation Subset: IM |
Affiliation:
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School of Women's and Infants' Health, The University of Western Australia, Subiaco, Western Australia 6009, Australia. graeme.polglase@uwa.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchoalveolar Lavage Fluid / immunology, microbiology Disease Models, Animal Female Gestational Age Inflammation Mediators / metabolism Lung / immunology, microbiology*, pathology, physiopathology Monocytes / immunology, microbiology Positive-Pressure Respiration / adverse effects* Pregnancy Pregnancy Complications, Infectious / immunology, microbiology* Premature Birth / immunology, microbiology*, physiopathology, therapy* Pulmonary Surfactants / pharmacology Sheep Tidal Volume Time Factors Ureaplasma / pathogenicity* Ureaplasma Infections / complications, immunology, microbiology* Ventilator-Induced Lung Injury / etiology*, immunology, physiopathology, prevention & control |
| Grant Support | |
ID/Acronym/Agency:
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12714//PHS HHS; K08HL097085/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Inflammation Mediators; 0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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