Document Detail


Ventilation and gas exchange during phasic hindlimb exercise in the dog.
MedLine Citation:
PMID:  468603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the importance of the major neural afferent component from the exercising extremities in exercise hyperpnea, rhythmic contraction of hindlimb muscles was produced in the dog, by electrically stimulating the peripheral cut ends of the sciatic and femoral nerves, bilaterally, for 4- to 5-min periods. VE, VCO2, and VO2 were computed breath-by-breath and PaCO2 was monitored continuously with an indwelling arterial electrode. During exercise, VO2 and VCO2 were approximately doubled in the steady state, rising with t1/2 of 25 +/- 2 and 35 +/- 4 s, respectively. VE increased within five breaths after exercise onset, and thereafter rose to a steady state with a t1/2 of 37 +/- 5 s. Mean PaCO2 increased transiently within the 1st min of stimulation but was not significantly different from control in the steady state. We conclude that the major neural afferent component from the contracting muscles is not an obligatory requirement for normal ventilatory response in the steady state of phasic exercise.
Authors:
M L Weissman; K Wasserman; D J Huntsman; B J Whipp
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  46     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-10-17     Completed Date:  1979-10-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  878-84     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Afferent Pathways / physiology
Animals
Blood Pressure
Carbon Dioxide / blood
Dogs
Hindlimb / innervation
Lung / physiology
Muscles / innervation
Physical Exertion*
Reflex*
Respiration*
Sciatic Nerve / physiology*
Tidal Volume
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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