Document Detail

Ventilation Heterogeneity in Obesity.
MedLine Citation:
PMID:  24651986     Owner:  NLM     Status:  Publisher    
Obesity is associated with important decrements in lung volumes. Despite this, ventilation remains normally or near normally distributed at least for moderate decrements in functional residual capacity (FRC). We tested the hypothesis that this is because maximum flow increases presumably as a result of an increased lung elastic recoil. Forced expiratory flows corrected for thoracic gas compression volume, lung volumes, and forced oscillation technique at 5-11-19Hz were measured in 133 healthy subjects with a BMI ranging from 18 to 50 kg•m(-2). Short-term temporal variability of ventilation heterogeneity was estimated from the inter-quartile range of the frequency distribution of the difference in inspiratory resistance between 5 and 19 Hz (R5-19_IQR). FRC % predicted negatively correlated with body mass index (r= -0.72, p<0.001) and with an increase in slope of either maximal (r= -0.34, p<0.01) or partial flow-volume curves (r= -0.30, p<0.01). Together with a slight decrease in residual volume, this suggests an increased lung elastic recoil. Regression analysis of R5-19_IQR against FRC % predicted and expiratory reserve volume (ERV) yielded significantly higher correlation coefficients by non-linear than linear fitting models (r(2) = 0.40 vs. 0.30 for FRC% predicted and r(2) = 0.28 vs. 0.19 for ERV). In conclusion, temporal variability of ventilation heterogeneities increases in obesity only when FRC falls approximately below 65% of predicted or ERV below 0.6 L. Above these thresholds distribution is quite well preserved presumably as a result of an increase in lung recoil.
Riccardo Giovanni Pellegrino; Alessandro Gobbi; Andrea Antonelli; Roberto Torchio; Carlo Gulotta; Giulia Michela Pellegrino; Raffaele L Dellaca; Robert E Hyatt; Vito Brusasco
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-20
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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