Document Detail

Venous thrombosis following the use of intermediate purity FVIII concentrate to treat patients with von Willebrand's disease.
MedLine Citation:
PMID:  12353065     Owner:  NLM     Status:  MEDLINE    
We describe four patients with von Willebrand's disease (VWD) who experienced venous thrombosis after treatment with an intermediate purity factor VIII (FVIII) concentrate (Haemate P3) was used to cover invasive or surgical procedures. Most patients had additional risk factors for venous thromboembolism (VTE) and it is difficult to be certain of the contribution of the concentrate to the VTE. In view of the recognised association between high factor VIII activity (FVIII:C) levels and VTE there is a physiological basis for this complication and it is important to consider this when administering FVIII containing concentrates to VWD patients.
M Makris; B Colvin; V Gupta; M L Shields; M P Smith
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  88     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-01     Completed Date:  2003-08-25     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  387-8     Citation Subset:  IM    
Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, UK.
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MeSH Terms
Aged, 80 and over
Factor VIII / adverse effects*,  therapeutic use
Middle Aged
Risk Factors
Surgical Procedures, Operative / adverse effects
Venous Thrombosis / chemically induced*,  etiology
von Willebrand Diseases / complications*,  therapy
Reg. No./Substance:
9001-27-8/Factor VIII
Comment In:
Thromb Haemost. 2002 Sep;88(3):378-9   [PMID:  12353063 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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