Document Detail

Venous thrombosis among patients with AIDS.
MedLine Citation:
PMID:  14979401     Owner:  NLM     Status:  MEDLINE    
Thrombosis has been considered an uncommon complication in patients with AIDS. In a 42-month period, 28 adult male homosexuals with AIDS experienced 34 thrombotic events. All but three received HAART regimen, two a successful round of double nucleoside analog therapy, and one patient received no treatment. Median age of group was 38.5 years (range, 24 to 56 years). Median time from HIV infection to thrombosis was 40.5 months (range, 3 to 108 months). No patient had previous thrombosis, family history of thrombosis, or prothrombotic conditions. There were 31 deep vein thromboses, two pulmonary thromboembolisms, and one renal vein thrombosis. Six patients had two thrombotic events. The rate of thrombosis during the 42-month study period was 1.52% (cumulative incidence = 0.30%/year), while the rate of thrombosis in 600 patients before the era of protease inhibitor therapy was 0.33% (cumulative incidence approximately 0.055%/year) (p < 0.001). Due to high incidence of thrombotic recurrences and hemorrhagic complications while using oral anticoagulants, acetylsalicylic acid was initiated; no thrombotic episodes were recorded while using this drug. Protein C and protein S deficiency were found in nine and two patients, respectively. Two patients had lupus anticoagulant and two activated protein C resistance (APCR) without FV Leiden mutation (APCR test was negative after initial screening). Fifteen patients had no thrombophilic abnormalities. These data suggest that protease inhibitors could be a risk factor for venous thrombosis not due to thrombophilic abnormalities but likely related to abnormalities in platelets or endothelium.
Abraham Majluf-Cruz; Mara Silva-Estrada; Rita Sánchez-Barboza; Guadalupe Montiel-Manzano; Sandra Treviño-Pérez; Mario Santoscoy-Gómez; Adriana Ruiz de Chávez-Ochoa; Norma Corona-de la Peña; Leopoldo Nieto-Cisneros
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  10     ISSN:  1076-0296     ISO Abbreviation:  Clin. Appl. Thromb. Hemost.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-02-24     Completed Date:  2004-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Unidad de Investigación en Epidemiología Clínica, Hospital General Regional Gabriel Mancera, IMSS, Mexico City, Mexico.
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MeSH Terms
Acquired Immunodeficiency Syndrome / blood,  complications*,  drug therapy
Activated Protein C Resistance
Aspirin / therapeutic use
HIV Protease Inhibitors / adverse effects
Lupus Coagulation Inhibitor
Middle Aged
Protein C Deficiency
Protein S Deficiency
Venous Thrombosis / blood,  chemically induced*,  etiology
Reg. No./Substance:
0/HIV Protease Inhibitors; 0/Lupus Coagulation Inhibitor; 50-78-2/Aspirin

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