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Venous thrombosis after radiofrequency ablation for hepatocellular carcinoma.
MedLine Citation:
PMID:  22109305     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: This study was designed to evaluate the frequency, morphological patterns, sequential changes, and clinical significance of venous thrombosis after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC).
MATERIALS AND METHODS: A total of 1379 RFAs performed in 1046 patients with HCC (mean tumor size, 1.93 cm) were surveyed. We retrospectively reviewed all radiologic reports before and after RFA and selected 15 patients with newly developed procedure-related venous thrombosis. Procedure-related thrombosis was defined as being adjacent to the ablation zone and developing within 4 months after the procedure. We evaluated the frequency, morphological patterns, sequential changes, and clinical course of venous thrombosis (mean follow-up, 662.9 days). Four cases with local tumor progression were identified among the 15 patients, and their clinical implications were evaluated.
RESULTS: A total of 15 venous thromboses (1.08%; 12 portal and three hepatic veins) developed after RFA (range, 0-128 days; mean, 37 days). The thromboses were found in central (n = 10), peripheral (n = 4), and both central and peripheral (n = 1) locations in the ablation zones. Thrombosis was decreased in nine (69.2%), persisted in one (7.6%), and increased in three (23.0%) of 13 patients who underwent follow-up CT for more than 12 months. Local tumor progression was noted in four patients (26.6%); it abutted to venous thrombosis in two patients, separated from the venous thrombosis in one patient, and exhibited malignant thrombosis in one patient.
CONCLUSION: The development of portal or hepatic venous thromboses after RFA in patients with HCC is rare and usually is associated with favorable prognoses. Further investigation is warranted to elucidate whether venous thrombosis after RFA is related to local tumor progression around ablation zones.
Ah Yeong Kim; Hyunchul Rhim; Minjung Park; Min Woo Lee; Young-Sun Kim; Dongil Choi; Hyo K Lim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  197     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1474-80     Citation Subset:  AIM; IM    
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea.
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