| Venous thromboembolism in women. | |
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MedLine Citation:
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PMID: 18687764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The risk of venous thromboembolism (VTE) varies throughout a woman's life and is associated primarily with underlying hormonal exposure. Alteration in hemostatic mechanisms, including resistance to activated protein C, may explain this altered risk. Initially, development of VTE with the use of contraception in young adulthood may reveal inherited thrombophilia. Pregnancy, and particularly the post-partum period, likely confer the greatest risk of VTE, but the absolute risk is small. Guidelines for prevention of VTE during pregnancy are based on personal or family history of VTE, and known inherited thrombophilia. Use of hormone replacement therapy later in life is associated with increased risk of VTE, and may be safest if given as an estrogen-only preparation to young postmenopausal women for less than 5 years. Universal screening for thrombophilia prior to pregnancy or initiating hormonal therapy is not recommended; however, selected testing in high-risk groups may be warranted. The lack of firm recommendations for the prevention of VTE in women highlights the need for future investigation aimed at identifying high-risk groups and evaluating the efficacy of prophylactic measures. |
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Authors:
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Suman Rathbun |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Vascular medicine (London, England) Volume: 13 ISSN: 1358-863X ISO Abbreviation: Vasc Med Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-08 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
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Languages: eng Pagination: 255-66 Citation Subset: IM |
Affiliation:
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Non-invasive Vascular Laboratories, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. suman-rathbun@ouhsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Contraception
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adverse effects Estrogen Replacement Therapy / adverse effects Female Humans Pregnancy Pregnancy Complications, Cardiovascular / epidemiology*, etiology, prevention & control Risk Factors Venous Thromboembolism / epidemiology*, etiology, prevention & control |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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