| Venous thromboembolism in pregnancy: prophylaxis and treatment with low molecular weight heparin. | |
| | |
MedLine Citation:
|
PMID: 19916891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the safety of individually dosed low molecular weight heparin (LMWH) for prophylaxis and treatment of thromboembolic complications in pregnancy. DESIGN: Cohort study with a chronologic register-based control group. SETTING: Department of Obstetrics and Gynecology, Hillerød Hospital, Denmark. POPULATION: All 166 women treated with LMWH in pregnancy between 1 January 2001 and 31 December 2005. METHODS: Women treated with LMWH in pregnancy were identified and individual case records reviewed retrospectively. General data on the LMWH-treated women were compared to the 18,020 untreated pregnancies within the same period and with 306 matched controls as regards to postpartum hemorrhage (PPH). MAIN OUTCOME MEASURES: Side effects of treatment, thromboembolic manifestations, postpartum bleeding and obstetric outcome. RESULTS: There were no thromboembolic events during therapy, few side effects of treatment and no osteoporotic fractures or episodes of heparin-induced thrombocytopenia. The 166 pregnancies resulted in 159 live infants. There was a significantly higher risk of preterm delivery (13% vs. 6%) and intrauterine growth restriction (4.4% vs. 3.5%). Delivery by cesarean section was more common in these high-risk LMWH-treated pregnancies (33.1%) than in untreated pregnancies (19.2%). In the LMWH-group, the occurrence of PPH was 7.2% compared with 8.8% in the matched untreated control group (p = 0.675). None of the events in the LMWH group were serious and all 166 women were in good health at discharge. CONCLUSIONS: Individually dosed LMWH is well tolerated and safe for prophylaxis and treatment of thromboembolic complications during pregnancy, delivery and the postpartum period. |
| | |
Authors:
|
Anita Sylvest Andersen; Jørgen G Berthelsen; Thomas Bergholt |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta obstetricia et gynecologica Scandinavica Volume: 89 ISSN: 1600-0412 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2010 |
Date Detail:
|
Created Date: 2009-12-21 Completed Date: 2010-01-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: England |
Other Details:
|
Languages: eng Pagination: 15-21 Citation Subset: IM |
Affiliation:
|
Department of Gynecology and Obstetrics, Hillerød Hospital, Hillerød, Denmark. asan@noh.regionh.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anticoagulants / administration & dosage* Cesarean Section / statistics & numerical data Dalteparin / administration & dosage Female Fetal Growth Retardation / epidemiology Fibrinolytic Agents / administration & dosage Gestational Age Heparin, Low-Molecular-Weight / administration & dosage* Humans Obstetric Labor, Premature / epidemiology Pregnancy Pregnancy Complications, Cardiovascular / drug therapy*, prevention & control Pregnancy Outcome Retrospective Studies Venous Thromboembolism / drug therapy*, prevention & control |
| Chemical | |
Reg. No./Substance:
|
0/Anticoagulants; 0/Dalteparin; 0/Fibrinolytic Agents; 0/Heparin, Low-Molecular-Weight; 0/tinzaparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of preoperative criteria used to predict lymph node metastasis in endometrial cancer.
Next Document: Changed indications for cesarean sections.