| Venous thromboembolism and cancer. | |
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MedLine Citation:
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PMID: 10331099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The association of thrombosis with malignant disease has been recognized for well over 100 years. Evidence from experimental and clinical studies indicates that the haemostatic system is involved in the growth, invasion and metastasis of tumours. Laboratory parameters of haemostasis are frequently deranged in patients with cancer and overt thrombosis is common spontaneously where it may be the first sign of malignancy or secondary to therapy. The mechanisms by which coagulation activation facilitates the malignant process remain to be completely elucidated, but it is clear that cells and proteins of the coagulation and fibrinolytic systems are involved at many steps in the processes of tumour growth and dissemination. The low-molecular-weight heparins with their well-proven safety and efficacy profiles offer unique modalities for the prevention and treatment of cancer-associated thrombosis. They may also play a role in overall mortality reduction in patients with malignant disease. |
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Authors:
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A K Kakkar; F de Lorenzo; G F Pineo; R C Williamson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Baillière's clinical haematology Volume: 11 ISSN: 0950-3536 ISO Abbreviation: Baillieres Clin. Haematol. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1999-06-29 Completed Date: 1999-06-29 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8800474 Medline TA: Baillieres Clin Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 675-87 Citation Subset: IM |
Affiliation:
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Department of Surgery, Imperial College School of Medicine, Hammersmith Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
/
adverse effects,
therapeutic use Blood Coagulation* Fibrinolytic Agents / adverse effects, therapeutic use Humans Neoplasms / blood*, complications*, drug therapy, physiopathology Risk Factors Venous Thrombosis / blood*, complications*, drug therapy, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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