Document Detail

Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality.
MedLine Citation:
PMID:  17938798     Owner:  NLM     Status:  MEDLINE    
Venous thromboembolism (VTE) is often asymptomatic, mis-diagnosed, and unrecognized at death, and there is a lack of routine postmortem examinations. These factors are thought to result in marked underestimates ofVTE incidence. The objective of our study was to estimate the total burden of VTE within the European Union (EU) per annum. An epidemiological model was constructed to estimate the number of community- and hospital-acquired incidents and recurrent cases (attack rate) of nonfatal VTE and VTE-related deaths, as well as incident and prevalent cases of post-thrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension (PH) occurring in the EU per annum. Individual models were developed for six EU countries. The models were populated with data from published literature and, where necessary, expert opinions. The findings were tested using probabilistic sensitivity analyses. The estimated total number of symptomaticVTE events (range based on probabilistic sensitivity analysis) per annum within the six EU countries was 465,715 (404,664-538,189) cases of deep-vein thrombosis, 295,982 (242,450-360,363) cases of pulmonary embolism (PE), and 370,012 (300,193-483,108) VTE-related deaths. Of these deaths, an estimated 27,473 (7%) were diagnosed as being antemortem; 126,145 (34%) were sudden fatal PE, and 217,394 (59%) followed undiagnosed PE. Almost three-quarters of all VTE-related deaths were from hospital-acquired VTE. VTE is a major health problem in the EU, with over one million VTE events or deaths per annum in the six countries examined. Given the availability of effective VTE prophylaxis, many of these events and deaths could have been prevented. These results have important implications for the allocation of healthcare resources.
Alexander T Cohen; Giancarlo Agnelli; Frederick A Anderson; Juan I Arcelus; David Bergqvist; Josef G Brecht; Ian A Greer; John A Heit; Julia L Hutchinson; Ajay K Kakkar; Dominique Mottier; Emmanuel Oger; Meyer-Michel Samama; Michael Spannagl;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  98     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-16     Completed Date:  2008-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  756-64     Citation Subset:  IM    
Vascular Medicine, Department of Surgery, King's College Hospital, London, SE5 9RS, UK.
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MeSH Terms
Anticoagulants / therapeutic use
Hypertension, Pulmonary / epidemiology,  mortality
Postthrombotic Syndrome / epidemiology,  mortality
Pulmonary Embolism / epidemiology,  mortality
Venous Thromboembolism / epidemiology*,  mortality*
Venous Thrombosis / epidemiology*,  mortality*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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