Document Detail


Venous thromboembolic disease in congestive heart failure.
MedLine Citation:
PMID:  20662869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Congestive heart failure (CHF) is a medical condition associated with a relatively high risk of venous thromboembolism (VTE). Without thromboprophylaxis, venographically proven deep vein thrombosis occurs in 10% to 22% of hospitalized patients with CHF. Although the elevated VTE risk associated with CHF has been attributed to a variety of abnormalities in the context of Virchow's triad, newer information suggests that an associated chronic inflammatory state may be culpable. Both traditional VTE risk factors and cardiac-specific risk factors further increase the risk of VTE in patients with CHF. Severe left ventricular dysfunction, clinical instability (New York Heart Association class III-IV), young age, and/or right ventricular dysfunction appear to enhance the VTE risk associated with CHF. Grade IA pharmacologic thromboprophylactic recommendations for the hospitalized CHF patient include low molecular weight-heparin, fondaparinux, and low-dose unfractionated heparin. Regrettably, a variance in societal guidelines on the importance of VTE in hospitalized CHF patients may lead to underutilization of thromboprophylaxis.
Authors:
Steven M Dean; William Abraham
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  16     ISSN:  1751-7133     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-28     Completed Date:  2011-06-02     Revised Date:  2011-10-19    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-9     Citation Subset:  IM    
Copyright Information:
2010 Wiley Periodicals, Inc.
Affiliation:
Department of Cardiovascular Medicine, The Ohio State University College of Medicine, Columbus, USA. steven.dean@osumc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anticoagulants / therapeutic use
Confidence Intervals
Enoxaparin / therapeutic use
Female
Fibrinolytic Agents / therapeutic use
Heart Failure / complications*,  physiopathology
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Retrospective Studies
Risk
Risk Factors
Stroke Volume
United States
Venous Thromboembolism / etiology*,  mortality,  prevention & control
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Enoxaparin; 0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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