| Venous thromboembolic disease in congestive heart failure. | |
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MedLine Citation:
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PMID: 20662869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congestive heart failure (CHF) is a medical condition associated with a relatively high risk of venous thromboembolism (VTE). Without thromboprophylaxis, venographically proven deep vein thrombosis occurs in 10% to 22% of hospitalized patients with CHF. Although the elevated VTE risk associated with CHF has been attributed to a variety of abnormalities in the context of Virchow's triad, newer information suggests that an associated chronic inflammatory state may be culpable. Both traditional VTE risk factors and cardiac-specific risk factors further increase the risk of VTE in patients with CHF. Severe left ventricular dysfunction, clinical instability (New York Heart Association class III-IV), young age, and/or right ventricular dysfunction appear to enhance the VTE risk associated with CHF. Grade IA pharmacologic thromboprophylactic recommendations for the hospitalized CHF patient include low molecular weight-heparin, fondaparinux, and low-dose unfractionated heparin. Regrettably, a variance in societal guidelines on the importance of VTE in hospitalized CHF patients may lead to underutilization of thromboprophylaxis. |
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Authors:
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Steven M Dean; William Abraham |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Congestive heart failure (Greenwich, Conn.) Volume: 16 ISSN: 1751-7133 ISO Abbreviation: Congest Heart Fail Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2011-06-02 Revised Date: 2011-10-19 |
Medline Journal Info:
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Nlm Unique ID: 9714174 Medline TA: Congest Heart Fail Country: United States |
Other Details:
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Languages: eng Pagination: 164-9 Citation Subset: IM |
Copyright Information:
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2010 Wiley Periodicals, Inc. |
Affiliation:
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Department of Cardiovascular Medicine, The Ohio State University College of Medicine, Columbus, USA. steven.dean@osumc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anticoagulants / therapeutic use Confidence Intervals Enoxaparin / therapeutic use Female Fibrinolytic Agents / therapeutic use Heart Failure / complications*, physiopathology Humans Logistic Models Male Middle Aged Odds Ratio Retrospective Studies Risk Risk Factors Stroke Volume United States Venous Thromboembolism / etiology*, mortality, prevention & control Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Enoxaparin; 0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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