| Venous oxygen saturation during normovolaemic haemodilution in the pig. | |
| | |
MedLine Citation:
|
PMID: 16095457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Hypovolaemia may be considered to represent a volume-restricted cardiac output (CO), but CO varies inversely with the haemoglobin concentration (Hb) and a maximal mixed venous oxygen saturation (SvO2) may be a better target for volume administration than a maximal CO. METHODS: In 10 anaesthetized pigs, volume loading with 6% hydroxyethyl starch was performed to obtain a maximal SvO2 followed by normovolaemic haemodilution with 6% hydroxyethyl starch. RESULTS: Volume loading increased SvO2 from 55.0+/-5.2% to 64.8+/-9.0% (mean+/-SD) associated with an increase in CO (2.3+/-0.4 to 3.5+/-0.9 l/min) and central venous oxygen saturation (ScvO2; 68.2+/-9.3% to 79.4+/-7.2%; P<0.05). Heart rate (HR), mean arterial (MAP), central venous (CVP), pulmonary arterial mean (PAMP), and occlusion pressures (PAOP) increased as well (P<0.05). In contrast, during progressive haemodilution, SvO2 and ScvO2 remained statistically unchanged until the haemoglobin concentration had decreased from 5.5+/-0.4 to 2.9+/-0.2 mM, while CO and HR increased at a haemoglobin value of 4.4+/-0.4 and 4.0+/-0.4 mM and CVP and PAOP decreased at a haemoglobin of 4.0+/-0.4 and 2.9+/-0.2 mM, respectively (P<0.05) leaving MAP unaffected. CONCLUSION: This study found that volume loading increased cardiac output and mixed and central venous oxygen saturations in parallel, but during normovolaemic haemodilution an increase in cardiac output left mixed and central venous oxygen saturations statistically unchanged until haemoglobin concentration was reduced by approximately 50%. Accordingly, volume therapy should be directed to maintain a high venous oxygen saturation rather than a change in cardiac output. |
| | |
Authors:
|
T Krantz; J Warberg; N H Secher |
Related Documents
:
|
2539937 - Time course and nature of postprandial haemodynamic changes in normal man. 18379977 - Measurement of hemodynamic and anatomic parameters in a swine arteriovenous fistula model. 6978097 - Superior vena cava syndrome as a cause of pleural effusion. 18372737 - Wise-2005: developing a non-invasive method to monitor cardiovascular deconditioning. 1536117 - Estimation of right ventricular pressure in children by thallium-201 myocardial imaging... 2412007 - Position of calcium antagonists in antihypertensive therapy. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta anaesthesiologica Scandinavica Volume: 49 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2005 Sep |
Date Detail:
|
Created Date: 2005-08-12 Completed Date: 2005-11-08 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: Denmark |
Other Details:
|
Languages: eng Pagination: 1149-56 Citation Subset: IM |
Affiliation:
|
Copenhagen Muscle Research Center, Department of Anesthesia, Rigshospitalet, Denmark. torbenkrantz@dadlnet.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Gas Analysis / methods Blood Pressure / drug effects Female Heart Rate / drug effects Hemodilution / methods* Hemodynamics / drug effects Hemoglobins / drug effects Hetastarch / administration & dosage Models, Animal Oxygen / blood* Plasma Substitutes / administration & dosage Swine Veins / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins; 0/Plasma Substitutes; 7782-44-7/Oxygen; 9005-27-0/Hetastarch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antithrombin III pretreatment reduces neutrophil recruitment into the lung and skeletal muscle tissu...
Next Document: Respiration can be monitored by photoplethysmography with high sensitivity and specificity regardles...