| Venous obstruction and cerebral perfusion during experimental cardiopulmonary bypass. | |
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MedLine Citation:
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PMID: 20696750 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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To investigate the effects on cerebral perfusion by experimental venous congestion of the superior vena cava (SVC) during bicaval cardiopulmonary bypass (CPB) at 34 °C, pigs were subjected to SVC obstruction at levels of 75%, 50%, 25% and 0% of baseline SVC flow at two arterial flow levels (low, LQ, high, HQ). The cerebral perfusion was examined with near-infrared spectroscopy (NIRS), cerebral microdialysis and blood gas analysis. SVC obstruction caused significant decreases in the NIRS tissue oxygenation index (TOI) and in SVC oxygen saturations (P<0.05, both groups), while the mixed venous saturation was decreased only in the LQ group. Sagittal sinus venous saturations were measured in the HQ group and found significantly reduced in response to venous congestion (P<0.05). No microdialysis changes were seen at the group level, however, individual ischemic patterns in terms of concomitant venous desaturation, decreased TOI and increased lactate/pyruvate occurred in both groups. The total venous drainage remained stabile throughout the experiment, indicating increased flow in the inferior vena cava cannula. The results indicate that SVC congestion may impair cerebral perfusion especially in the case of compromised arterial flow during CPB. Reduced SVC cannula flow may pass undetected during bicaval CPB, if SVC flow is not specifically monitored. |
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Authors:
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Thomas Tovedal; Ove Jonsson; Vitas Zemgulis; Gunnar Myrdal; Stefan Thelin; Fredrik Lennmyr |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-09 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 11 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 561-6 Citation Subset: IM |
Affiliation:
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Department of Surgical Sciences, Section of Cardiothoracic Surgery and Anaesthesiology, Uppsala University Hospital, Entrance 50/7th Floor, SE-751 85 Uppsala, Sweden. thomas.tovedal@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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