| Venous malformation: update on aetiopathogenesis, diagnosis and management. | |
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MedLine Citation:
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PMID: 20870869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this review was to discuss the current knowledge on aetiopathogenesis, diagnosis and therapeutic management of venous malformations (VMs). VMs are slow-flow vascular anomalies. They are simple, sporadic or familial (cutaneomucosal VMs or glomuvenous malformations), combined (e.g. capillaro-venous and capillaro-lymphaticovenous malformations) or syndromic (Klippel-Trenaunay, blue rubber bleb naevus and Maffucci). Genetic studies have identified causes of familial forms and of 40% of sporadic VMs. Another diagnostic advancement is the identification of elevated D-dimer level as the first biomarker of VMs within vascular anomalies. Those associated with pain are often responsive to low-molecular-weight heparin, which should also be used to avoid disseminated intravascular coagulopathy secondary to intervention, especially if fibrinogen level is low. Finally, development of a modified sclerosing agent, ethylcellulose-ethanol, has improved therapy. It is efficient and safe, and widens indications for sclerotherapy to sensitive and dangerous areas such as hands, feet and periocular area. |
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Authors:
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A Dompmartin; M Vikkula; L M Boon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Phlebology / Venous Forum of the Royal Society of Medicine Volume: 25 ISSN: 1758-1125 ISO Abbreviation: Phlebology Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-02-01 Revised Date: 2011-11-10 |
Medline Journal Info:
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Nlm Unique ID: 9012921 Medline TA: Phlebology Country: England |
Other Details:
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Languages: eng Pagination: 224-35 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Université de Caen Basse Normandie, CHU Caen, Caen, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Disease Management Hemangioma Humans Nevus Vascular Malformations* / diagnosis, etiology, therapy |
| Grant Support | |
ID/Acronym/Agency:
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P01 AR048564/AR/NIAMS NIH HHS; P01 AR048564-08/AR/NIAMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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