Document Detail


Venous hypertension and the inflammatory cascade: major manifestations and trigger mechanisms.
MedLine Citation:
PMID:  16193224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent histologic and immunocytochemical evidence of venous leg ulcers supports the hypothesis that lesions observed at different stages of chronic venous insufficiency may be associated with, and possibly caused by, an inflammatory process. Evidence has been obtained that venous valve deficiency may be associated with leukocyte infiltration into valve leaflets; therefore, it is hypothesized that an essential event in the inflammatory cascade is the enzymatic degradation of the valve leaflets and venous wall. The metalloproteinases (MMP) in veins exposed to elevated pressures up to 6 weeks were examined in a rat femoral fistula model with venous hypertension. Zymography shows increased activity of pro-MMP-2 at 3 and 6 weeks. MMP-2 and MMP-9 activity was predominantly observed at days 7 and 21 after creation of the fistula. The degree of extracellular matrix remodeling correlates with the morphological finding of macroscopic lesions. Therefore, the MMP-2 and MMP-9 activation is already present in veins days after exposure to elevated blood pressure and coincides with periods of early alterations in the valve morphology and early forms of reflux.
Authors:
Luigi Pascarella; Alexander Penn; Geert W Schmid-Schönbein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Angiology     Volume:  56 Suppl 1     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-09-29     Completed Date:  2005-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S3-10     Citation Subset:  IM    
Affiliation:
Department of Bioengineering, Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, CA 92093-0412, USA.
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MeSH Terms
Descriptor/Qualifier:
Humans
Hypertension / physiopathology*
Inflammation*
Matrix Metalloproteinase 2 / physiology
Matrix Metalloproteinase 9 / physiology
Varicose Ulcer / physiopathology*
Venous Insufficiency / complications
Chemical
Reg. No./Substance:
EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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