| Venous hypertension induces increased platelet reactivity and accumulation in patients with chronic venous insufficiency. | |
| | |
MedLine Citation:
|
PMID: 16703192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The objective of this study was to determine whether there are changes in platelet activation and rheology in patients with chronic venous insufficiency (CVI) and what their impact is on this disease. Anticoagulated peripheral venous blood collected from 21 patients with CVI and 13 normal control subjects in different bodily positions was incubated either with 0.5 mumol/L adenosine diphosphate (ADP) or without agonist and analyzed by whole blood flow cytometry. Soluble P-selectin was analyzed in obtained sera by enzyme-linked immunosorbent assay. Platelet count was determined by a whole blood analyzer. Circulating platelets were more reactive to stimulation with 0.5 mumol/L ADP in patients with CVI compared with control subjects. There was no statistically significant change in platelet activation without ADP and the level of soluble P-selectin as a function of posture. Under simulated venous hypertension, platelet accumulation was observed in patients with CVI. Patients with CVI had increased platelet reactivity and accumulation during orthostasis, suggesting this might be a contributory factor to CVI pathogenesis. |
| | |
Authors:
|
Xinwu Lu; Yujie Chen; Yin Huang; Weimin Li; Mier Jiang |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Angiology Volume: 57 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 2006 May-Jun |
Date Detail:
|
Created Date: 2006-05-16 Completed Date: 2006-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
|
Languages: eng Pagination: 321-9 Citation Subset: IM |
Affiliation:
|
Department of Vascular Surgery, Shanghai 9th People's Hospital affiliated Shanghai Second Medical University, Shanghai, China. luxinwu@yahoo.com.cn |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Diphosphate
/
pharmacology Aged Blood Platelets / drug effects, metabolism Chronic Disease Dizziness / blood Female Flow Cytometry Humans Hypertension / blood, physiopathology* Male Middle Aged P-Selectin / blood Platelet Activation* Platelet Count Supine Position Venous Insufficiency / blood, physiopathology* |
| Chemical | |
Reg. No./Substance:
|
0/P-Selectin; 58-64-0/Adenosine Diphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Microalbuminuria is determined by systolic and pulse pressure over a 12-year period and related to p...
Next Document: Cramps and muscular pain: prevention with pycnogenol in normal subjects, venous patients, athletes, ...