Document Detail

Venous gas embolism--a comparison of carbon dioxide and helium in pigs.
MedLine Citation:
PMID:  9350372     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The use of helium for insufflation during laparoscopic surgery avoids hypercarbia and acidosis associated with absorbed CO2, but the effects of helium gas embolism are unknown. We compared the effects of CO2 with He gas embolism on survival, haemodynamic variables, oxygenation, and ventilation in pigs. METHODS: Anaesthetized juvenile pigs were given progressively larger boluses of either CO2 (n = 5) or He (n = 4) into the right atrium. Measurements of haemodynamic variables, oxygenation, and PETCO2 were made before and after each gas injection. RESULTS: All animals survived injection of 300 ml CO2 while no animal survived more than 120 ml He (P < 0.01). Mean arterial pressure decreased more after 60 ml He (99 +/- 14 to 44 +/- 20 mmHg) than after 60 ml CO2 (110 +/- 12 to 88 +/- 14 mmHg, P < 0.001). Cardiac output did not change at any injection volume. The PETCO2 decreased more after 60 ml He (30 +/- 2 to 3 +/- 6 mmHg) than after 60 ml CO2 (35 +/- 3 to 30 +/- 3 mmHg, P < 0.001). Only the He group showed a decrease in PaO2 (190 +/- 51 to 68 +/- 22 mmHg at 60 ml, P < 0.05). CONCLUSION: Helium gas embolism has a greater deleterious effect than CO2 gas embolism on survival, MAP, PETCO2, and PaO2. These different effects of gas embolism should be recognized when considering the use of helium or other insoluble gases for abdominal laparoscopic insufflation.
B Rudston-Brown; P N Draper; B Warriner; K R Walley; P T Phang
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  44     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-04     Completed Date:  1997-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1102-7     Citation Subset:  IM; S    
Division of General Surgery, St. Paul's Hospital, Vancouver, British Columbia, Canada.
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MeSH Terms
Blood Pressure / drug effects,  physiology
Carbon Dioxide / adverse effects*
Cardiac Output / drug effects,  physiology
Embolism, Air / physiopathology*
Helium / adverse effects*
Oxygen Consumption / physiology
Respiratory Mechanics / physiology
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7440-59-7/Helium
Comment In:
Can J Anaesth. 1998 Sep;45(9):913-4   [PMID:  9818120 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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