| Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats. | |
| | |
MedLine Citation:
|
PMID: 12798955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Apelin is an endogenous depressor peptide for the G protein-coupled APJ receptor. Our hypothesis is that apelin is a venodilator, and it reduces mean circulatory filling pressure (MCFP; index of venous tone). Dose-response curves of apelin (10, 20 and 40 nmol/kg) or vehicle (0.9% NaCl) were constructed in two groups each of conscious, unrestrained rats: unblocked rats and rats pretreated with mecamylamine (Mec; ganglionic blocker) and noradrenaline (NA; to restore vascular tone). The vehicle had no effects in the unblocked or ganglionic-blocked rats. Apelin decreased mean arterial pressure (MAP) and increased heart rate (HR), but it did not alter mean circulatory filling pressure in the unblocked rats. In the ganglionic-blocked rats, apelin did not alter heart rate but decreased mean arterial pressure and mean circulatory filling pressure. These results show that apelin is an arterial and venous dilator in vivo. The depressor effect of apelin is accompanied by tachycardia which is abolished by ganglion blockade. |
| | |
Authors:
|
Xing Cheng; Xiao Shuo Cheng; Catherine C Y Pang |
Related Documents
:
|
7114255 - Analysis of adrenergic effects of the anesthetics inactin and alpha-chloralose. 9609765 - Prostaglandin e2 and aggressive factors increase the gland luminal pressure in the rat ... 18997985 - Cardiovascular effects of helichrysum ceres s moore [asteraceae] ethanolic leaf extract... 3613605 - A new blood pressure measuring apparatus equipped with a microcomputer system for consc... 14675055 - Angiotensin ii receptor blockade prevents acute renal sodium retention induced by low l... 17072065 - The role of cardiac and vascular components in blood pressure variability during volunt... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of pharmacology Volume: 470 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2003 Jun |
Date Detail:
|
Created Date: 2003-06-11 Completed Date: 2004-03-04 Revised Date: 2011-08-03 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 171-5 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects, physiology Carrier Proteins / pharmacology*, physiology Consciousness / drug effects*, physiology Dose-Response Relationship, Drug Heart Rate / drug effects, physiology Ligands Male Peptides / pharmacology, physiology Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled / agonists, physiology* Vasodilation / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Apln protein, rat; 0/Aplnr protein, rat; 0/Carrier Proteins; 0/Ligands; 0/Peptides; 0/Receptors, G-Protein-Coupled |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiple cellular electrophysiological effects of azimilide in canine cardiac preparations.
Next Document: The administration of alpha-melanocyte-stimulating hormone protects the ischemic/reperfused myocardi...