Document Detail


Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats.
MedLine Citation:
PMID:  12798955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apelin is an endogenous depressor peptide for the G protein-coupled APJ receptor. Our hypothesis is that apelin is a venodilator, and it reduces mean circulatory filling pressure (MCFP; index of venous tone). Dose-response curves of apelin (10, 20 and 40 nmol/kg) or vehicle (0.9% NaCl) were constructed in two groups each of conscious, unrestrained rats: unblocked rats and rats pretreated with mecamylamine (Mec; ganglionic blocker) and noradrenaline (NA; to restore vascular tone). The vehicle had no effects in the unblocked or ganglionic-blocked rats. Apelin decreased mean arterial pressure (MAP) and increased heart rate (HR), but it did not alter mean circulatory filling pressure in the unblocked rats. In the ganglionic-blocked rats, apelin did not alter heart rate but decreased mean arterial pressure and mean circulatory filling pressure. These results show that apelin is an arterial and venous dilator in vivo. The depressor effect of apelin is accompanied by tachycardia which is abolished by ganglion blockade.
Authors:
Xing Cheng; Xiao Shuo Cheng; Catherine C Y Pang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  470     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-11     Completed Date:  2004-03-04     Revised Date:  2011-08-03    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects,  physiology
Carrier Proteins / pharmacology*,  physiology
Consciousness / drug effects*,  physiology
Dose-Response Relationship, Drug
Heart Rate / drug effects,  physiology
Ligands
Male
Peptides / pharmacology,  physiology
Rats
Rats, Sprague-Dawley
Receptors, G-Protein-Coupled / agonists,  physiology*
Vasodilation / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Apln protein, rat; 0/Aplnr protein, rat; 0/Carrier Proteins; 0/Ligands; 0/Peptides; 0/Receptors, G-Protein-Coupled

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