| Venous activated clotting time after intra-arterial heparin: effect of site of administration and timing of sampling. | |
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MedLine Citation:
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PMID: 8808070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is not known how the site of arterial administration of heparin and the timing of the activated clotting time (ACT) measurement affect the ACT during coronary interventions. We measured serial femoral venous ACTs after heparin was administered either via the angioplasty guiding catheter into the central aorta or peripherally via a sheath into the femoral artery. When heparin was administered into the central aorta, the ACT rose gradually and by 60 sec plateaued without further increase. When heparin was given into the femoral artery, the ACT displayed a marked "overshoot" early (20-270 sec after heparin) and did not plateau until sometime between 270 and 800 sec after heparin administration. We conclude that the site of administration and timing of venous sampling markedly affect the measured ACT during coronary interventions. Operators should be aware of these effects when assessing the accuracy of the ACT during coronary interventions. |
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Authors:
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R A Kerensky; G J Azar; B Bertolet; J A Hill; M A Kutcher |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular diagnosis Volume: 37 ISSN: 0098-6569 ISO Abbreviation: Cathet Cardiovasc Diagn Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-12-04 Completed Date: 1996-12-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7508512 Medline TA: Cathet Cardiovasc Diagn Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 151-3 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Florida Health Science Center, Gainesville 32610-0277, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Aorta Blood Coagulation / drug effects* Coronary Disease / blood*, therapy Femoral Artery Heparin / administration & dosage* Humans Infusions, Intra-Arterial Whole Blood Coagulation Time |
| Chemical | |
Reg. No./Substance:
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9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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