| Venous valvular stasis-associated hypoxia and thrombosis: what is the link? | |
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MedLine Citation:
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PMID: 21034220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review focuses on the role of the venous valves in the genesis of thrombus formation in venous thromboembolic disease (VTE). Clinical VTE and the evidence for the valvular origin of venous thrombosis are reviewed. Virchow's triad is then used as a framework for discussion to approach the question posed regarding the link between venous valvular stasis-associated hypoxia and thrombosis. Thus, the effects of blood flow stasis, hypercoagulability of blood, and the characteristics of the vessel wall within the venous valvular sinus are assessed in turn. |
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Authors:
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Edwin G Bovill; Albert van der Vliet |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annual review of physiology Volume: 73 ISSN: 1545-1585 ISO Abbreviation: Annu. Rev. Physiol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-07-08 Revised Date: 2012-03-22 |
Medline Journal Info:
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Nlm Unique ID: 0370600 Medline TA: Annu Rev Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 527-45 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Vermont College of Medicine, Burlington, 05405, USA. edwin.bovill@uvm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Anoxia / physiopathology* Blood Coagulation / physiology Early Growth Response Protein 1 / physiology Female Humans Hypoxia-Inducible Factor 1 / physiology Male Reactive Oxygen Species / metabolism Thrombosis / epidemiology, physiopathology* Veins / physiopathology Venous Valves / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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P01 HL046703/HL/NHLBI NIH HHS; R01 HL085646/HL/NHLBI NIH HHS; R01 HL085646-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/EGR1 protein, human; 0/Early Growth Response Protein 1; 0/Hypoxia-Inducible Factor 1; 0/Reactive Oxygen Species |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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