| Venous congestion and endothelial cell activation in acute decompensated heart failure. | |
| | |
MedLine Citation:
|
PMID: 20424989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Despite accumulating clinical evidence supporting a key role for venous congestion in the development of acute decompensated heart failure (ADHF), there remain several gaps in our knowledge of the pathophysiology of ADHF. Specifically, the biomechanically driven effects of venous congestion on the vascular endothelium (the largest endocrine/paracrine organ of the body), on neurohormonal activation, and on renal and cardiac dysfunction remain largely unexplored. We propose that venous congestion is a fundamental, hemodynamic stimulus for vascular inflammation, which plays a key role in the development and possibly the resolution of ADHF through vascular, humoral, renal, and cardiac mechanisms. A better understanding of the role of venous congestion and endothelial activation in the pathophysiology of ADHF may provide a strong rationale for near-future testing of treatment strategies that target biomechanically driven inflammation. Targeting vascular and systemic inflammation before symptoms arise may prevent progression to overt clinical decompensation in the ADHF syndrome. |
| | |
Authors:
|
Anjali Ganda; Duygu Onat; Ryan T Demmer; Elaine Wan; Timothy J Vittorio; Hani N Sabbah; Paolo C Colombo |
Related Documents
:
|
1570329 - Endothelial cells regulate cardiac contractility. 21565189 - Cigb-300, a proapoptotic peptide, inhibits angiogenesis in vitro and in vivo. 21795519 - Covalently grafted vegf165 in hydrogel models up-regulates the cellular pathways associ... 9663979 - Endothelial outgrowth and the subsequent cell transition in the culture of embryonic at... 21889439 - Bistability of cell adhesion in shear flow. 21778339 - Pericytes promote endothelial cell survival through induction of autocrine vegf-a signa... 3464959 - Expression and function of neural cell adhesion molecule during limb regeneration. 7430259 - Fibronectin from aged fibroblasts is defective in promoting cellular adhesion. 7543849 - Beta 1 integrins do not have a major role in keratinocyte intercellular adhesion. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Current heart failure reports Volume: 7 ISSN: 1546-9549 ISO Abbreviation: Curr Heart Fail Rep Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-25 Completed Date: 2010-10-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101196487 Medline TA: Curr Heart Fail Rep Country: United States |
Other Details:
|
Languages: eng Pagination: 66-74 Citation Subset: IM |
Affiliation:
|
Division of Nephrology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. ag355@columbia.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Endothelial Cells
/
metabolism* Heart Failure / complications*, physiopathology* Humans Hyperemia / etiology* Severity of Illness Index |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: What should be done with a dilated bile duct?
Next Document: Testosterone Deficiency and Exercise Intolerance in Heart Failure: Treatment Implications.