| Venodilator action of an organotransition-metal nitrosyl complex. | |
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MedLine Citation:
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PMID: 11834253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitrovasodilators, such as nitroglycerin, cause endothelium-independent dilatation of arterial and capacitance vessels via the release of nitric oxide (NO). This study examined the venodilator effect of CpCr(NO)(2)Cl (organotransition-metal nitrosyl complex) relative to that of nitroglycerin in conscious, unrestrained rats. Organotransition-metal nitrosyl complexes have releasable NO directly attached to metal centres. The dose-response effects of CpCr(NO)(2)Cl and nitroglycerin on the mean arterial pressure and the mean circulatory filling pressure (index of the body venous tone) were obtained in rats continuously infused with either normal saline or noradrenaline. The results show that both CpCr(NO)(2)Cl and nitroglycerin reduced the mean arterial pressure in rats with normal or elevated vasomotor tone. However, maximum depressor response of CpCr(NO)(2)Cl was greater than that of nitroglycerin. In vehicle-treated rats, both compounds increased the mean circulatory filling pressure. In rats with elevated vasomotor tone through the infusion of noradrenaline, both agents reduced the mean circulatory filling pressure. These results show that CpCr(NO)(2)Cl is an efficacious depressor and venodilator agent. |
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Authors:
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Kenneth S Poon; Catherine C Y Pang |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 436 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-08 Completed Date: 2002-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 107-10 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, 2176 Health Sciences Mall, V6T 1Z3, Vancouver, B.C., Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Circulation / drug effects Blood Pressure / drug effects Dose-Response Relationship, Drug Heart Rate / drug effects Male Nitric Oxide Donors / pharmacology* Nitroglycerin / pharmacology Organometallic Compounds / pharmacology* Rats Rats, Sprague-Dawley Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Nitric Oxide Donors; 0/Organometallic Compounds; 0/Vasodilator Agents; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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