Document Detail


Venodilator action of an organotransition-metal nitrosyl complex.
MedLine Citation:
PMID:  11834253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitrovasodilators, such as nitroglycerin, cause endothelium-independent dilatation of arterial and capacitance vessels via the release of nitric oxide (NO). This study examined the venodilator effect of CpCr(NO)(2)Cl (organotransition-metal nitrosyl complex) relative to that of nitroglycerin in conscious, unrestrained rats. Organotransition-metal nitrosyl complexes have releasable NO directly attached to metal centres. The dose-response effects of CpCr(NO)(2)Cl and nitroglycerin on the mean arterial pressure and the mean circulatory filling pressure (index of the body venous tone) were obtained in rats continuously infused with either normal saline or noradrenaline. The results show that both CpCr(NO)(2)Cl and nitroglycerin reduced the mean arterial pressure in rats with normal or elevated vasomotor tone. However, maximum depressor response of CpCr(NO)(2)Cl was greater than that of nitroglycerin. In vehicle-treated rats, both compounds increased the mean circulatory filling pressure. In rats with elevated vasomotor tone through the infusion of noradrenaline, both agents reduced the mean circulatory filling pressure. These results show that CpCr(NO)(2)Cl is an efficacious depressor and venodilator agent.
Authors:
Kenneth S Poon; Catherine C Y Pang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  436     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, 2176 Health Sciences Mall, V6T 1Z3, Vancouver, B.C., Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Circulation / drug effects
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Heart Rate / drug effects
Male
Nitric Oxide Donors / pharmacology*
Nitroglycerin / pharmacology
Organometallic Compounds / pharmacology*
Rats
Rats, Sprague-Dawley
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Nitric Oxide Donors; 0/Organometallic Compounds; 0/Vasodilator Agents; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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