| Venodilating action of nipradilol (K-351) in the pithed rat pretreated with dihydroergotamine. | |
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MedLine Citation:
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PMID: 2866266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The venodilating action of nipradilol was investigated by monitoring arterial blood pressure (BP), cardiac output (CO), heart rate (HR) and central venous pressure (CVP) in pithed rats treated with dihydroergotamine (DHE). DHE increased CVP and produced a simultaneous rise in BP and CO without appreciable changes in total peripheral resistance (TPR) and HR, indicating that DHE reduces venous capacity through venoconstriction. Nipradilol caused a fall in CVP, BP and CO without changing the TPR in the DHE-pretreated rat. By comparison, hydralazine reduced BP and TPR without changes in CO. Propranolol produced only a transient decrease in BP and TPR. These results indicate that nipradilol dilates venous capacitance vessels and thereby decreases cardiac filling pressure in animals with high venous tone, whereas hydralazine preferentially dilates resistance vessels. |
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Authors:
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Y Shirasawa; M Fujii; M Nakamura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese journal of pharmacology Volume: 39 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1986-01-15 Completed Date: 1986-01-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 77-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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pharmacology* Animals Decerebrate State Dihydroergotamine / pharmacology* Hemodynamics / drug effects* Hydralazine / pharmacology Male Propanolamines / pharmacology* Propranolol / pharmacology Rats Rats, Inbred Strains Time Factors Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Propanolamines; 0/Vasodilator Agents; 511-12-6/Dihydroergotamine; 525-66-6/Propranolol; 81486-22-8/K 351; 86-54-4/Hydralazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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