Document Detail

Venoarterial communication as a mechanism for localized signaling in the rat uterine circulation.
MedLine Citation:
PMID:  12501079     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Venoarterial communication describes the phenomenon whereby molecular signals in a vein directly influence an adjacent artery. The objective of this study was to investigate, in vitro, the existence of such a pathway in the uterine circulation of the rat. STUDY DESIGN: Paired uterine vessels from late pregnant and virgin rats were pressurized and studied in a dual-perfusion vasograph. Veins were perfused with phenylephrine and endothelin-1, alone or in combination, and the vasoactive responses of both vessels were recorded. RESULTS: Venous perfusion of phenylephrine resulted in concentration-dependent arterial, but not venous, constriction. Conversely, veins, but not arteries, demonstrated concentration-dependent constriction to intravenous endothelin-1. Superfusion of endothelin-1 constricted both vessels. Coperfusion of endothelin-1 and phenylephrine constricted the veins and attenuated the previously observed arterial response to intravenous phenylephrine. CONCLUSION: The results of this study support the existence of venoarterial communication within the uterine circulation through an endothelin-1-sensitive pathway.
Gerard Celia; George Osol
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  187     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-25     Completed Date:  2003-01-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1653-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington 05405, USA.
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MeSH Terms
Arteries / drug effects,  metabolism*
Endothelin-1 / administration & dosage
Phenylephrine / administration & dosage
Rats, Sprague-Dawley
Signal Transduction*
Uterus / blood supply*
Vasoconstriction / drug effects
Vasoconstrictor Agents / administration & dosage
Veins / drug effects,  metabolism*
Grant Support
Reg. No./Substance:
0/Endothelin-1; 0/Vasoconstrictor Agents; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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