Document Detail


Venoarterial communication as a mechanism for localized signaling in the rat uterine circulation.
MedLine Citation:
PMID:  12501079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Venoarterial communication describes the phenomenon whereby molecular signals in a vein directly influence an adjacent artery. The objective of this study was to investigate, in vitro, the existence of such a pathway in the uterine circulation of the rat. STUDY DESIGN: Paired uterine vessels from late pregnant and virgin rats were pressurized and studied in a dual-perfusion vasograph. Veins were perfused with phenylephrine and endothelin-1, alone or in combination, and the vasoactive responses of both vessels were recorded. RESULTS: Venous perfusion of phenylephrine resulted in concentration-dependent arterial, but not venous, constriction. Conversely, veins, but not arteries, demonstrated concentration-dependent constriction to intravenous endothelin-1. Superfusion of endothelin-1 constricted both vessels. Coperfusion of endothelin-1 and phenylephrine constricted the veins and attenuated the previously observed arterial response to intravenous phenylephrine. CONCLUSION: The results of this study support the existence of venoarterial communication within the uterine circulation through an endothelin-1-sensitive pathway.
Authors:
Gerard Celia; George Osol
Related Documents :
21972929 - Surgical treatment of circumflex coronary aneurysm with fistulous connection to coronar...
21490939 - Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular cal...
16965229 - Umbilical artery pulsatility index: reliability at different sampling sites.
7503319 - A wave transmission model of the umbilicoplacental circulation based on hemodynamic mea...
3959539 - An indwelling catheter for the collection of cat uterine fluids.
21393589 - Cerebral microembolism during coronary angiography: a randomized comparison between fem...
17395869 - Long-term outcome after angioplasty and stenting for symptomatic vertebral artery steno...
19930979 - Mitral valve repair in the treatment of mitral regurgitation.
2847509 - Effects of bradykinin and leukotrienes b4 and d4 on the bovine bronchial artery in vitr...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  187     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-25     Completed Date:  2003-01-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1653-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington 05405, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / drug effects,  metabolism*
Endothelin-1 / administration & dosage
Female
Perfusion
Phenylephrine / administration & dosage
Pregnancy
Rats
Rats, Sprague-Dawley
Signal Transduction*
Uterus / blood supply*
Vasoconstriction / drug effects
Vasoconstrictor Agents / administration & dosage
Veins / drug effects,  metabolism*
Grant Support
ID/Acronym/Agency:
HL63078/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Endothelin-1; 0/Vasoconstrictor Agents; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Structural remodeling of rat uterine veins in pregnancy.
Next Document:  Comparison of pregnancy dating by last menstrual period, ultrasound scanning, and their combination.