Document Detail


Veno-occlusive disease in pediatric patients after hematopoietic stem cell transplantation: relevance of activated coagulation and fibrinolysis markers and natural anticoagulants.
MedLine Citation:
PMID:  21336167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prediction of veno-occlusive disease (VOD), its precise diagnosis, and treatment have been the subject of various studies, but still remain unclear. Our goal was to investigate the levels of activated coagulation and fibrinolysis markers and natural anticoagulants in pediatric patients with VOD after hematopoietic stem cell transplantation (HSCT). We investigated 47 pediatric patients: 20 with neuroblastoma, 17 with leukemias, and 10 with lymphomas and measured the values of antithrombin (AT), protein C (PC), fibrinogen (FI), thrombin AT complex, prothrombin fragments 1+2 (F1+2), and D-dimer from day -7 to day +30 post-HSCT. Patients were monitored for the occurrence of VOD, and it occurred in 10 patients at a median post-HSCT day of 17.5 (range: 2 to 28 d). In the VOD group, at baseline the levels of FI were significantly lower, and on days +7 and +14 a relevant difference existed in F1+2 levels. The levels of PC were significantly lower on day +14. Logistic multivariate regression analysis between the groups showed significantly different D-dimer levels on day +14. On day +30, the levels of PC, AT, and F1+2 were different between these 2 groups of patients. The levels of D-dimer and F1+2 were increased, and PC and FI decreased before the clinical onset of VOD. The parameter differences may have a predictive value in VOD onset, which makes them candidates to be routinely monitored in patients after HSCT.
Authors:
Dragana Jevtic; Zeljko Zecevic; Dobrila Veljkovic; Violeta Dopsaj; Zoran Radojicic; Ivo Elezovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  33     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-23     Completed Date:  2011-06-02     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-34     Citation Subset:  IM    
Affiliation:
Bone Marrow Transplantation Unit and Coagulation Laboratory, Mother and Child Health Care Institute of Serbia Dr Vukan Cupic, Institute for Statistics, University of Belgrade, Belgrade, Serbia. drjevtic@beotel.rs
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anticoagulants / blood*
Blood Coagulation*
Child
Child, Preschool
Female
Fibrin Fibrinogen Degradation Products / analysis
Fibrinolysis*
Hematopoietic Stem Cell Transplantation / adverse effects*
Hepatic Veno-Occlusive Disease / blood,  etiology*
Humans
Infant
Male
Transplantation Conditioning
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D

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