| Venlafaxine inhibits the development and differentiation of dendritic cells through the regulation of p-glycoprotein. | |
| | |
MedLine Citation:
|
PMID: 21605706 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Dendritic cells (DC) are professional antigen-presenting cells that have the ability to detect infectious materials; antigens to T lymphocytes, and serve as a bridge between innate and adaptive immunities. DC express the ATP-binding cassette transporters P-glycoprotein (P-gp). P-gp is a 170-kDa transmembrane protein encoded by the mdr-1 gene, a member of highly conserved superfamily of ATP-binding cassette transport proteins. Functionally, P-gp transporters have been described to be required for efficient DC and T cell migration. We report for the first time, at the best of our knowledge, P-gp is also required for DC development and differentiation in mouse bone marrow-derived DC. In this study, we found that an mdr-1 gene and P-gp protein level was increased during DC development and LPS-induced maturation. Moreover, the activity of P-gp was increased LPS-induced DC maturation. Next, we have attempted to determine whether the modulation of P-gp regulates surface molecules expression and cytokine production in DC. Specifically, down-regulation of P-gp by Venlafaxine (VLX) inhibits the differentiation of DC and cytokine production, such as IL-1, IL-10, and IL-12 during DC maturation. Moreover, the P-gp-decreased DC by VLX was displayed impaired induction of T cell polarizations, proliferation, and cytokine production, including IFN-γ, IL-4, and IL-2. Taken together, these findings also broaden current perspective concerning our understanding of the immunopharmacological functions of VLX and the development of therapeutic adjuvants for the treatment of DC-related acute and chronic diseases. |
| | |
Authors:
|
Jun Sik Lee; In Duk Jung; Chang-Min Lee; Kyung Tae Noh; Jin Wook Park; Kwang Hee Son; Deok Rim Heo; Yong Kyoo Shin; Daejin Kim; Yeong-Min Park |
Related Documents
:
|
15296476 - The role of peripheral benzodiazepine receptors on the function and survival of isolate... 12700196 - Chemical anoxia delays germ cell apoptosis in the human testis. 17195096 - Acidic extracellular ph shifts colorectal cancer cell death from apoptosis to necrosis ... 10510466 - Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochond... 8133856 - Immune mechanisms of cardiac disease. 12941656 - Ribavirin or cpg dna sequence-modulated dendritic cells decrease the ige level and airw... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-20 |
Journal Detail:
|
Title: International immunopharmacology Volume: - ISSN: 1878-1705 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Biology, College of Natural Science, Chosun University, Gwangju 501-759, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Optimal sample storage and extraction procotols for reliable multilocus genotyping of the human para...
Next Document: Why are there no proven therapies for genetic mitochondrial diseases?