| Venlafaxine-induced acute eosinophilic pneumonia. | |
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MedLine Citation:
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PMID: 21762842 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: Acute Eosinophilic Pneumonia (AEP) is a severe syndrome which can be potentially induced by many reasons, including drugs. It is characterized by pulmonary infiltrates, peripheral blood eosinophilia and respiratory failure. AEP has rarely been associated with antidepressant treatment. CASE REPORT: We report a case of an 80-year-old woman who presented with fever, lung infiltrates, peripheral blood eosinophilia and acute respiratory failure. All evidence charge venlafaxine as the only possible causal factor. The syndrome rapidly resolved after discontinuation of the drug and upon reception of corticosteroids in low doses. The patient had a past medical history of AEP induced by sertraline and a recent medical history of Acute Lung Injury on the context of acute pancreatitis during treatment with venlafaxine. DISCUSSION: Pathophysiological mechanisms implicated in the development of AEP in our patient seems to be associated with eotaxin and serotonin eosinophilic-specific chemoattracting action. CONCLUSION: This is a case report with clinical adverse reaction of AEP in two antidepressant agents (venlafaxine and sertraline) with a similar neurochemical mechanism of action via the serotoninergic system. |
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Authors:
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Evi Tsigkaropoulou; Despina Hatzilia; Emmanouil Rizos; Christos Christodoulou; Stylianos Loukides; Spyridon Papiris; Lefteris Lykouras |
Publication Detail:
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Type: Journal Article Date: 2011-05-05 |
Journal Detail:
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Title: General hospital psychiatry Volume: 33 ISSN: 1873-7714 ISO Abbreviation: Gen Hosp Psychiatry Publication Date: 2011 Jul-Aug |
Date Detail:
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Created Date: 2011-07-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905527 Medline TA: Gen Hosp Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 411.e7-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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National and Kapodistrian University of Athens, Medical School, 2nd Department of Psychiatry, University "ATTIKON" General Hospital, 12462 Athens, Greece. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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