| Vemurafenib: the first drug approved for BRAF-mutant cancer. | |
| | |
MedLine Citation:
|
PMID: 23060265 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The identification of driver oncogenes has provided important targets for drugs that can change the landscape of cancer therapies. One such example is the BRAF oncogene, which is found in about half of all melanomas as well as several other cancers. As a druggable kinase, oncogenic BRAF has become a crucial target of small-molecule drug discovery efforts. Following a rapid clinical development path, vemurafenib (Zelboraf; Plexxikon/Roche) was approved for the treatment of BRAF-mutated metastatic melanoma in the United States in August 2011 and the European Union in February 2012. This Review describes the underlying biology of BRAF, the technology used to identify vemurafenib and its clinical development milestones, along with future prospects based on lessons learned during its development. |
| | |
Authors:
|
Gideon Bollag; James Tsai; Jiazhong Zhang; Chao Zhang; Prabha Ibrahim; Keith Nolop; Peter Hirth |
Related Documents
:
|
20884635 - Thirteenth aacr special conference on cancer epigenetics. 23253475 - Telomerase and the search for the end of cancer. 11770825 - Roger yate stanier, 1916-1982: a transcendent journey. 23480555 - Exploring the biology of cancer of unknown primary: breakthroughs and drawbacks. 20162455 - Biobanking of human pancreas cancer tissue: impact of ex-vivo procurement times on rna ... 2200755 - Coincident implantation, growth and interaction sites within the liver of cancer and re... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-12 |
Journal Detail:
|
Title: Nature reviews. Drug discovery Volume: - ISSN: 1474-1784 ISO Abbreviation: Nat Rev Drug Discov Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101124171 Medline TA: Nat Rev Drug Discov Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Plexxikon, 91 Bolivar Drive, Berkeley, California 94710, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessing the Accuracy of SAPT(DFT) Interaction Energies by Comparison with Experimentally Derived N...
Next Document: c-Met function requires N-linked glycosylation modification of pro-Met.