| Velocity response curves support the role of continuous entrainment in circadian clocks. | |
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MedLine Citation:
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PMID: 20348465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Circadian clocks drive endogenous oscillations in organisms across the tree of life. The Earth's daily light/dark cycle entrains these clocks to the environment. Two major theories of light entrainment have been presented in the literature. The discrete theory emphasizes the instantaneous phase-shifting behavior of short pulses of light, and the continuous theory emphasizes changes to the period of oscillations in constant-light conditions. Historically, the primary tool for predicting and understanding discrete entrainment has been the PRC, which measures discrete adjustments to the clock's phase. The authors present a unified theory, which relies on a velocity response curve (VRC), similar in shape to a PRC, but that describes continuous adjustments to the clock's speed. The VRC explains data from both discrete and continuous light experiments and is therefore an invaluable tool to understand entrainment. The authors relate VRC features to specific entrainment behaviors, such as seasonal adjustments to the phase of entrainment. Furthermore, they estimate a VRC from PRC data and successfully reproduce additional PRC data. Finally, they entrain a VRC-based model to natural light/dark cycles, demonstrating the unified theory's ability to predict clock behavior in the face of a fluctuating signal. The results indicate that a VRC-based model not only provides a comprehensive understanding of entrainment but also has excellent predictive capabilities. |
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Authors:
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Stephanie R Taylor; Alexis B Webb; Katherine S Smith; Linda R Petzold; Francis J Doyle |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of biological rhythms Volume: 25 ISSN: 1552-4531 ISO Abbreviation: J. Biol. Rhythms Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700115 Medline TA: J Biol Rhythms Country: United States |
Other Details:
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Languages: eng Pagination: 138-49 Citation Subset: IM |
Affiliation:
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Department of Computer Science, Colby College, Waterville, ME, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Biological Clocks / physiology* Circadian Rhythm / physiology* Cricetinae Light Mesocricetus Mice Models, Theoretical Oscillometry / methods Photic Stimulation Photoperiod Seasons Sunlight |
| Grant Support | |
ID/Acronym/Agency:
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EB007511/EB/NIBIB NIH HHS; GM078993/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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