Document Detail

Vegetative state and minimally conscious state: a review of the therapeutic interventions.
MedLine Citation:
PMID:  20460949     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The purpose of the present article is a systematic review of the proposed medical or surgical treatments in patients in chronic vegetative state (VS) or minimally conscious state (MCS), as well as of their mechanisms of action and limitations. METHODS: For this review, we have agreed to include patients in VS or MCS having persisted for over 6 months in posttraumatic cases, and over 3 months in nontraumatic cases, before the time of intervention. Searches were independently conducted by 2 investigators between May 2009 and September 2009 in the following databases: Medline, Web of Science and the Cochrane Library. The electronic search was complemented by cross-checking the references of all relevant articles. Overall, 16 papers were eligible for this systematic review. RESULTS: According to the 16 eligible studies, medical management by dopaminergic agents (levodopa, amantadine), zolpidem and median nerve stimulation, or surgical management by deep brain stimulation, extradural cortical stimulation, spinal cord stimulation and intrathecal baclofen have shown to improve the level of consciousness in certain cases. CONCLUSION: The treatments proposed for disorders of consciousness have not yet gained the level of 'evidence-based treatments'; moreover, the studies to date have led to inconclusiveness. The published therapeutic responses must be substantiated by further clinical studies of sound methodology.
Miltiadis Georgiopoulos; Paraskevi Katsakiori; Zinovia Kefalopoulou; John Ellul; Elisabeth Chroni; Constantine Constantoyannis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-05-12
Journal Detail:
Title:  Stereotactic and functional neurosurgery     Volume:  88     ISSN:  1423-0372     ISO Abbreviation:  Stereotact Funct Neurosurg     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-14     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902881     Medline TA:  Stereotact Funct Neurosurg     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  199-207     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
Functional Neurosurgery Unit, Department of Neurosurgery, Medical School of Patras, Patras, Greece.
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MeSH Terms
Baclofen / therapeutic use
Electric Stimulation Therapy
Persistent Vegetative State / therapy*
Pyridines / therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Pyridines; 1134-47-0/Baclofen; 82626-48-0/zolpidem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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