Document Detail

Vegan supplemented diet in nephrotic syndrome.
MedLine Citation:
PMID:  2129467     Owner:  NLM     Status:  MEDLINE    
Thirteen patients (7 males, 6 females, aged 17-68 years) affected by primary, steroid-resistant, nephrotic syndrome and normal renal function were treated with a vegan, low-protein (0.7 g/kg per day) diet supplemented with essential amino acids and Ketoanalogues (VSD) for 3.9 +/- 2.9 months. These patients were studied at the beginning (following an unrestricted protein diet (UPD) supplying about 1 g/kg per day of mixed proteins) and at the end of VSD period. Urinary protein excretion decreased from 8.7 +/- 2.6 to 5.6 +/- 2.4 g/day (P less than 0.01), serum total cholesterol from 334.6 +/- 97.1 to 275.6 +/- 49.4 mg/dl (P less than 0.05). Serum albumin, HDL-cholesterol, triglycerides, and anthropometric measurements (triceps skinfold thickness and middle arm muscle circumference) did not change. Urinary urea nitrogen decreased from 7.5 +/- 1.8 to 3.8 +/- 1.2 g/day (P less than 0.005), according to dietary prescriptions. Creatinine clearance changed from 104.4 +/- 28.7 to 89.3 +/- 16.7 ml/min (n.s.) and no correlation was found with the changes in urinary protein excretion. This data suggest that VSD reduces proteinuria and exerts favourable effects on hypercholesterolaemia. Protein malnutrition was absent in these patients, probably because of the essential amino acids and ketoanalogues supplementation.
G Barsotti; A Cupisti; E Morelli; F Ciardella; S Giovannetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  5 Suppl 1     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1990  
Date Detail:
Created Date:  1991-10-07     Completed Date:  1991-10-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  75-7     Citation Subset:  IM    
Clinica Medica I, Universitá degli Studi, Pisa, Italy.
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MeSH Terms
Amino Acids, Essential / administration & dosage
Diet, Vegetarian*
Dietary Proteins / administration & dosage
Evaluation Studies as Topic
Hypercholesterolemia / diet therapy
Middle Aged
Nephrotic Syndrome / blood,  diet therapy*,  urine
Proteinuria / diet therapy
Reg. No./Substance:
0/Amino Acids, Essential; 0/Dietary Proteins

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